Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | PRKAG1 | P54619 | 5/20 | 0.37 |
| ▸ | PRKAA1 | Q13131 | 5/20 | 0.37 |
| ▸ | PRKAB1 | Q9Y478 | 5/20 | 0.37 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | WRN | Q14191 | 1/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7741117 | 0.90 | PRKAG1 (0.37) | GSK3BCYP1A2PRKAG1PRKAA1PRKAB1 | |
| SCHEMBL7739842 | 0.89 | PRKAG1 (0.42) | CYP1A2PRKAG1PRKAA1PRKAB1KMT2A | |
| SCHEMBL7740612 | 0.89 | PRKAG1 (0.40) | GSK3BCYP1A2PRKAG1PRKAA1PRKAB1 | |
| SCHEMBL7740617 | 0.89 | PTGES (0.36) | PRKAG1PRKAA1PRKAB1GRIN2DGRIN3B | |
| SCHEMBL7741113 | 0.86 | IDH1 (0.41) | PRKAG1PRKAA1PRKAB1GRIN2DGRIN3B | |
| SCHEMBL7742768 | 0.85 | CYP1A2 (0.41) | GSK3BCYP1A2HSD17B10KMT2AGRIN2D | |
| SCHEMBL7741417 | 0.85 | CA12 (0.39) | CYP1A2PRKAG1PRKAA1PRKAB1 | |
| SCHEMBL7741254 | 0.85 | PTGES (0.37) | PRKAG1PRKAA1PRKAB1KMT2AGRIN2D | |
| SCHEMBL7742681 | 0.83 | CDK5 (0.35) | HSD17B10USP2KMT2AGRIN2DGRIN3B | |
| SCHEMBL7740551 | 0.82 | PRKAG1 (0.43) | GSK3BCYP1A2PRKAG1PRKAA1PRKAB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420386-B1 | SPINAL TRAUMATISM, EPILEPSY, CHRONIC NEURODEGENERATIVE DISEASES SUCH AS ALZHEIMER'S DISEASE, SCHIZOPHRENIA, LATERAL AMYOTROPHIC SCLEROSIS OR HUNTINGTON'S CHOREA. | LES LABORATORIES SERVIER (FR) | 2002-07-16 | — | — | US | disclosed |