Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | FASN | P49327 | 1/20 | 0.35 |
| ▸ | PRKAG1 | P54619 | 4/20 | 0.35 |
| ▸ | PRKAB1 | Q9Y478 | 4/20 | 0.35 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.35 |
| ▸ | UTRN | P46939 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7739842 | 0.89 | PRKAG1 (0.42) | PTGESKMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL7740612 | 0.89 | PRKAG1 (0.40) | KMT2AMEN1NPC1ALDH1A1HPGD | |
| SCHEMBL7741117 | 0.86 | PRKAG1 (0.37) | PTGESKMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL7739643 | 0.85 | GSK3B (0.37) | KMT2AKDM4EALDH1A1LMNAGAA | |
| SCHEMBL7739963 | 0.83 | KDM4E (0.37) | PTGESKMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL7740617 | 0.82 | PTGES (0.36) | PTGESRAB9APRKAG1PRKAB1PRKAA1 | |
| SCHEMBL7741113 | 0.82 | IDH1 (0.41) | KDM4EALDH1A1PRKAG1PRKAB1PRKAA1 | |
| SCHEMBL7741244 | 0.82 | PTGES (0.40) | PTGESGSTP1KMT2AMEN1FASN | |
| SCHEMBL7742768 | 0.82 | CYP1A2 (0.41) | KMT2AMEN1NPC1ALDH1A1LMNA | |
| SCHEMBL7741417 | 0.82 | CA12 (0.39) | PRKAG1PRKAB1PRKAA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420386-B1 | SPINAL TRAUMATISM, EPILEPSY, CHRONIC NEURODEGENERATIVE DISEASES SUCH AS ALZHEIMER'S DISEASE, SCHIZOPHRENIA, LATERAL AMYOTROPHIC SCLEROSIS OR HUNTINGTON'S CHOREA. | LES LABORATORIES SERVIER (FR) | 2002-07-16 | — | — | US | disclosed |