Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.32 |
| ▸ | CDK2 | P24941 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1184137 | 0.68 | — | — | |
| SCHEMBL10235421 | 0.68 | MAPK1 (0.33) | LMNAALDH1A1THRBTSHRMAPK1 | |
| SCHEMBL48370 | 0.67 | LTA4H (0.46) | ADORA2AADORA1 | |
| SCHEMBL10183093 | 0.65 | KDM4E (0.33) | LMNAALDH1A1THRBTSHRMAPK1 | |
| SCHEMBL19497078 | 0.64 | KDM4E (0.37) | LMNAALDH1A1THRBTSHRMAPK1 | |
| SCHEMBL19497168 | 0.63 | KDM4E (0.37) | LMNAALDH1A1THRBTSHRMAPK1 | |
| SCHEMBL19497169 | 0.63 | CDK2 (0.40) | LMNAALDH1A1THRBTSHRMAPK1 | |
| SCHEMBL19497079 | 0.63 | ALDH1A1 (0.33) | LMNAALDH1A1THRBTSHRMAPK1 | |
| SCHEMBL10281382 | 0.63 | TLR7 (0.37) | LMNAALDH1A1TSHRMAPK1SMN1; SMN2 | |
| SCHEMBL19419968 | 0.62 | KDM4E (0.47) | LMNAALDH1A1TSHRADORA3ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6413975-B1 | DISEASES WITH HIGH LEVELS OF INFLAMMATORY CYTOKINES; ASTHMA; ALLERGIES; INFLAMMATION; DEPRESSION; ALZHEIMER'S DISEASE; VASCULAR AND MULTI-IN-FARCT DEMENTIA | EURO-CELTIQUE, S.A. (LU) | 2002-07-02 | — | — | US | disclosed |
| US-6319928-B1 | ASTHMA, ALLERGIES, INFLAMMATION,DEPRESSION, DEMENTIA, ALZHEIMER'S DISEASE, VASCULAR AND MULTI-IN-FARCT DEMENTIA AND DISEASE CAUSED BY HUMAN IMMUNODEFICIENCY VIRUS TREATMENT; EFFICIENCY AND SELECTIVITY | EURO-CELTIQUE, S.A. (LU) | 2001-11-20 | — | — | US | disclosed |
| US-6294541-B1 | ENZYME INHIBITORS USING PURINE COMPOUNDS AS ANTIHISTAMINES | EURO-CELTIQUE S.A. (LU) | 2001-09-25 | — | — | US | disclosed |