Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHEB | Q15382 | 1/20 | 0.43 |
| ▸ | IDH1 | O75874 | 3/20 | 0.37 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.37 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.37 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.37 |
| ▸ | PRSS12 | P56730 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | FASN | P49327 | 1/20 | 0.34 |
| ▸ | MAP2 | P11137 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6935464 | 0.84 | PRKAG1 (0.43) | PRKAG1PRKAA1PRKAB1 | |
| SCHEMBL7740551 | 0.84 | PRKAG1 (0.43) | PRKAG1PRKAA1PRKAB1FASN | |
| SCHEMBL7742754 | 0.84 | PRKAG1 (0.42) | PRKAG1PRKAA1PRKAB1FASN | |
| SCHEMBL7741113 | 0.83 | IDH1 (0.41) | RHEBIDH1PRKAG1PRKAA1PRKAB1 | |
| SCHEMBL7741121 | 0.82 | IDH1 (0.36) | RHEBIDH1PRKAG1PRKAA1PRKAB1 | |
| SCHEMBL28747976 | 0.81 | PRKAG1 (0.37) | PRKAG1PRKAA1PRKAB1 | |
| SCHEMBL6940851 | 0.81 | TNKS (0.39) | PRKAG1PRKAA1PRKAB1 | |
| SCHEMBL7741098 | 0.81 | PTGS2 (0.38) | PRKAG1PRKAA1PRKAB1 | |
| SCHEMBL7741263 | 0.81 | GRIA1 (0.41) | — | |
| SCHEMBL7741244 | 0.80 | PTGES (0.40) | PRKAG1PRKAA1PRKAB1FASN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420386-B1 | SPINAL TRAUMATISM, EPILEPSY, CHRONIC NEURODEGENERATIVE DISEASES SUCH AS ALZHEIMER'S DISEASE, SCHIZOPHRENIA, LATERAL AMYOTROPHIC SCLEROSIS OR HUNTINGTON'S CHOREA. | LES LABORATORIES SERVIER (FR) | 2002-07-16 | — | — | US | disclosed |