Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 6/20 | 0.54 |
| ▸ | GRIA2 | P42262 | 6/20 | 0.54 |
| ▸ | GRIA3 | P42263 | 6/20 | 0.54 |
| ▸ | GRIA4 | P48058 | 6/20 | 0.54 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.44 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.44 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.44 |
| ▸ | GRIK4 | Q16099 | 1/20 | 0.44 |
| ▸ | GRIK5 | Q16478 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7741437 | 0.84 | GRIN2D (0.40) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL7739865 | 0.82 | GRIA1 (0.61) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL6928527 | 0.81 | PARP1 (0.40) | — | |
| SCHEMBL7740364 | 0.80 | GRIA1 (0.48) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL7735087 | 0.79 | NTRK1 (0.35) | — | |
| SCHEMBL7068983 | 0.77 | PARP1 (0.43) | — | |
| SCHEMBL6928804 | 0.77 | TRPV4 (0.31) | — | |
| SCHEMBL6923612 | 0.77 | CA1 (0.36) | — | |
| SCHEMBL7648893 | 0.76 | TAS2R14 (0.31) | — | |
| SCHEMBL6938546 | 0.76 | KDM4E (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420386-B1 | SPINAL TRAUMATISM, EPILEPSY, CHRONIC NEURODEGENERATIVE DISEASES SUCH AS ALZHEIMER'S DISEASE, SCHIZOPHRENIA, LATERAL AMYOTROPHIC SCLEROSIS OR HUNTINGTON'S CHOREA. | LES LABORATORIES SERVIER (FR) | 2002-07-16 | — | — | US | disclosed |