Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 4/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | CTSV | O60911 | 1/20 | 0.51 |
| ▸ | CTSL | P07711 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6562050 | 0.79 | GPR35 (0.53) | ALDH1A1SMN1; SMN2HTTTDP1MAPT | |
| SCHEMBL5786188 | 0.77 | KMT2A (0.56) | ALDH1A1SMN1; SMN2HTTTDP1MAPT | |
| SCHEMBL10502203 | 0.77 | ALDH1A1 (0.97) | ALDH1A1SMN1; SMN2HTTMAPTCYP3A4 | |
| SCHEMBL6677996 | 0.77 | GAA (0.57) | ALDH1A1SMN1; SMN2HTTTDP1MAPT | |
| SCHEMBL11278452 | 0.77 | ALDH1A1 (0.67) | ALDH1A1SMN1; SMN2HTTMAPTCTSV | |
| SCHEMBL3040101 | 0.76 | ALDH1A1 (1.00) | ALDH1A1SMN1; SMN2HTTMAPTCYP3A4 | |
| SCHEMBL6140205 | 0.76 | ALDH1A1 (0.62) | ALDH1A1SMN1; SMN2HTTTDP1MAPT | |
| SCHEMBL6255487 | 0.76 | ALDH1A1 (1.00) | ALDH1A1SMN1; SMN2HTTMAPTCYP3A4 | |
| SCHEMBL29805486 | 0.76 | ALDH1A1 (1.00) | ALDH1A1SMN1; SMN2HTTMAPTCYP3A4 | |
| SCHEMBL260006 | 0.76 | ALDH1A1 (0.70) | ALDH1A1SMN1; SMN2HTTTDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6414005-B1 | BRAIN DISORDERS; ALZHEIMER'S DISEASE; PARKINSON'S DISEASE | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2002-07-02 | — | — | US | disclosed |
| EP-1043312-A1 | HETEROCYCLIC COMPOUNDS HAVING NOS INHIBITORY ACTIVITIES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2000-10-11 | — | — | EP | disclosed |