Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | RORC | P51449 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | TERT | O14746 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | MLNR | O43193 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6157997 | 0.99 | ALDH1A1 (0.48) | ALDH1A1TDP1RORCRECQLCYP1A2 | |
| SCHEMBL10872909 | 0.83 | MAPT (0.58) | ALDH1A1TDP1RORCRECQLCYP1A2 | |
| SCHEMBL10874142 | 0.81 | TDP1 (0.54) | ALDH1A1TDP1RORCRECQLCYP1A2 | |
| SCHEMBL10874979 | 0.80 | TDP1 (0.70) | ALDH1A1TDP1RORCRECQLCYP1A2 | |
| SCHEMBL9795781 | 0.79 | ALDH1A1 (0.53) | ALDH1A1TDP1RORCRECQLCYP1A2 | |
| SCHEMBL4667768 | 0.78 | GAA (0.40) | ALDH1A1TDP1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6152534 | 0.77 | HRH3 (0.55) | ALDH1A1TDP1RORCRECQLCYP1A2 | |
| SCHEMBL6157990 | 0.75 | ALDH1A1 (0.50) | ALDH1A1TDP1RORCRECQLCYP1A2 | |
| SCHEMBL7163975 | 0.74 | LMNA (0.48) | ALDH1A1MAPTHSD17B10KMT2ALMNA | |
| SCHEMBL4667682 | 0.74 | CYP19A1 (0.60) | ALDH1A1TDP1MAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6419711-B1 | PHENOLIC COMPOUND COUPLER | L'OREAL (FR) | 2002-07-16 | — | — | US | disclosed |