Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | SDHB | P21912 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7089382 | 0.81 | PTGS2 (0.54) | PTGS2ESR1ESR2 | |
| SCHEMBL8802006 | 0.78 | ALOX5 (0.42) | PTGS2KMT2AALOX5MEN1POLB | |
| SCHEMBL8810671 | 0.78 | ALOX5 (0.46) | PTGS2KMT2AALOX5MEN1POLB | |
| SCHEMBL6735914 | 0.77 | BRAF (0.38) | PTGS2ESR1ESR2BRAF | |
| SCHEMBL8814347 | 0.77 | ALOX5 (0.40) | PTGS2KMT2AALOX5MEN1POLB | |
| SCHEMBL9079514 | 0.76 | PTGS2 (0.43) | PTGS2KMT2AALOX5MEN1POLB | |
| SCHEMBL6738959 | 0.76 | NR1H2 (0.35) | PTGS2ALOX5ESR1ESR2BRAF | |
| SCHEMBL6733161 | 0.75 | NR1H2 (0.40) | PTGS2KMT2ARAB9AESR1ESR2 | |
| SCHEMBL6723894 | 0.75 | ESR1 (0.40) | PTGS2ESR1ESR2BRAF | |
| SCHEMBL6734567 | 0.74 | SDHB (0.42) | PTGS2RAB9AALOX5ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6426360-B1 | ANTIARTHRITIC AGENTS | G D SEARLE & CO. | 2002-07-30 | — | — | US | disclosed |