Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.37 |
| ▸ | FEN1 | P39748 | 3/20 | 0.37 |
| ▸ | SCD | O00767 | 3/20 | 0.37 |
| ▸ | FADS1 | O60427 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.35 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | SDHB | P21912 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8814347 | 0.91 | ALOX5 (0.40) | ALOX5POLBMEN1KMT2APTGS2 | |
| SCHEMBL6729205 | 0.88 | PTGS2 (0.37) | ALOX5POLBMEN1KMT2APTGS2 | |
| SCHEMBL7087414 | 0.83 | PTGS2 (0.49) | ALOX5PTGS2ESR1ESR2SCD | |
| SCHEMBL6735304 | 0.82 | ESR1 (0.41) | ALOX5PTGS2ESR1ESR2SCD | |
| SCHEMBL9079514 | 0.81 | PTGS2 (0.43) | ALOX5POLBMEN1KMT2APTGS2 | |
| SCHEMBL8810671 | 0.80 | ALOX5 (0.46) | ALOX5POLBMEN1KMT2APTGS2 | |
| SCHEMBL7740641 | 0.78 | PTGS2 (0.42) | ALOX5POLBMEN1KMT2APTGS2 | |
| SCHEMBL6739929 | 0.76 | ESR1 (0.48) | ALOX5POLBMEN1KMT2APTGS2 | |
| SCHEMBL6740267 | 0.76 | PTGS2 (0.39) | ALOX5PTGS2BRAFPDE2AMAPK14 | |
| SCHEMBL6736839 | 0.75 | MAPK14 (0.39) | ALOX5ALOX5APFEN1BRAFSLC9A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772601-A1 | 4,5-SUBSTITUTED IMIDAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |