Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.44 |
| ▸ | IDH1 | O75874 | 3/20 | 0.37 |
| ▸ | GPR6 | P46095 | 3/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | ALB | P02768 | 1/20 | 0.32 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7734315 | 0.94 | TRPV4 (0.38) | TRPV4IDH1GPR6HDAC6 | |
| SCHEMBL7740698 | 0.82 | HDAC6 (0.41) | IDH1CYP11B2HDAC6CYP11B1MCHR1 | |
| SCHEMBL7733484 | 0.82 | HDAC6 (0.49) | TRPV4IDH1GPR6CYP11B2HDAC6 | |
| SCHEMBL7120051 | 0.79 | TRPV4 (0.38) | TRPV4HDAC6 | |
| SCHEMBL7742267 | 0.79 | HDAC6 (0.47) | TRPV4HDAC6 | |
| SCHEMBL7734423 | 0.79 | HDAC6 (0.47) | TRPV4IDH1HDAC6 | |
| SCHEMBL7115119 | 0.78 | HDAC6 (0.46) | TRPV4HDAC6 | |
| SCHEMBL7117894 | 0.78 | HDAC6 (0.48) | TRPV4HDAC6 | |
| SCHEMBL7121805 | 0.77 | HDAC6 (0.45) | TRPV4HDAC6MCHR1 | |
| SCHEMBL7740700 | 0.77 | HDAC6 (0.45) | TRPV4HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6413938-B1 | HERPES VIRUS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2002-07-02 | — | — | US | disclosed |
| EP-0970100-A1 | BENZIMIDAZOLE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2000-01-12 | — | — | EP | disclosed |
| WO-1998035977-A1 | BENZIMIDAZOLE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1998-08-20 | — | — | WO | disclosed |