Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.49 |
| ▸ | IDH1 | O75874 | 5/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.37 |
| ▸ | ADK | P55263 | 3/20 | 0.36 |
| ▸ | GPR6 | P46095 | 4/20 | 0.36 |
| ▸ | HSPA8 | P11142 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7734332 | 0.93 | HDAC6 (0.50) | HDAC6TRPV4IDH1ADKGPR6 | |
| SCHEMBL7742258 | 0.84 | HDAC6 (0.57) | HDAC6ADKHSPA8 | |
| SCHEMBL7740711 | 0.82 | TRPV4 (0.44) | HDAC6TRPV4IDH1CYP11B2CYP11B1 | |
| SCHEMBL7114288 | 0.81 | HDAC6 (0.49) | HDAC6TRPV4IDH1CYP11B2CYP11B1 | |
| SCHEMBL7117206 | 0.80 | HDAC6 (0.48) | HDAC6TRPV4IDH1ADK | |
| SCHEMBL7734525 | 0.80 | HDAC6 (0.57) | HDAC6TRPV4ADKHSPA8 | |
| SCHEMBL7215020 | 0.79 | HDAC6 (0.74) | HDAC6TRPV4ADKHSPA8 | |
| SCHEMBL7215024 | 0.79 | HDAC6 (0.74) | HDAC6TRPV4ADKHSPA8 | |
| SCHEMBL10308324 | 0.79 | HDAC6 (0.74) | HDAC6TRPV4ADKHSPA8 | |
| SCHEMBL7738034 | 0.79 | HDAC6 (0.56) | HDAC6CYP11B2CYP11B1HSPA8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6413938-B1 | HERPES VIRUS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2002-07-02 | — | — | US | disclosed |
| EP-0970100-A1 | BENZIMIDAZOLE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2000-01-12 | — | — | EP | disclosed |
| WO-1998035977-A1 | BENZIMIDAZOLE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1998-08-20 | — | — | WO | disclosed |