Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 5/20 | 0.45 |
| ▸ | GRIK1 | P39086 | 6/20 | 0.39 |
| ▸ | GRIK2 | Q13002 | 6/20 | 0.39 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NPY1R | P25929 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ADCY6 | O43306 | 3/20 | 0.37 |
| ▸ | ADCY3 | O60266 | 3/20 | 0.37 |
| ▸ | ADCY9 | O60503 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7742756 | 0.94 | PIN1 (0.42) | PIN1HDAC2HDAC6KDM4EMEN1 | |
| SCHEMBL7740709 | 0.85 | ADCY6 (0.46) | PIN1HDAC2HDAC6KDM4EMEN1 | |
| SCHEMBL7740789 | 0.84 | PIN1 (0.42) | PIN1GRIK1GRIK2GRIK3HDAC2 | |
| SCHEMBL7740792 | 0.84 | PIN1 (0.42) | PIN1GRIK1GRIK2GRIK3HDAC2 | |
| SCHEMBL7740794 | 0.84 | PIN1 (0.42) | PIN1GRIK1GRIK2GRIK3HDAC2 | |
| SCHEMBL7741056 | 0.83 | ALDH1A1 (0.44) | PIN1HDAC2HDAC6KDM4EMEN1 | |
| SCHEMBL7742656 | 0.82 | MMP12 (0.45) | PIN1GRIK1HDAC2HDAC6KDM4E | |
| SCHEMBL7741090 | 0.81 | ADCY6 (0.46) | PIN1HDAC2HDAC6KDM4EMEN1 | |
| SCHEMBL7739771 | 0.81 | ADCY6 (0.46) | PIN1HDAC2KDM4EMEN1NPC1 | |
| SCHEMBL7739485 | 0.80 | HDAC6 (0.46) | HDAC2HDAC6KDM4EMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420427-B1 | PREVENTION AND/OR TREATMENT OF RHEUMATOID DISEASES, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS, INTERSTITIAL NEPHRITIS, ARTERIOSCLEROSIS, PULMONARY EMPHYSEMA, CIRRHOSIS, CORNEA INJURY | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-07-16 | — | — | US | claimed |
| EP-1024134-A1 | AMINOBUTANOIC ACID DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2000-08-02 | — | — | EP | claimed |
| US-6420427-B1 | PREVENTION AND/OR TREATMENT OF RHEUMATOID DISEASES, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS, INTERSTITIAL NEPHRITIS, ARTERIOSCLEROSIS, PULMONARY EMPHYSEMA, CIRRHOSIS, CORNEA INJURY | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-1024134-A1 | AMINOBUTANOIC ACID DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2000-08-02 | — | — | EP | disclosed |