SCHEMBL7742016

SCHEMBL7742016

N#Cc1ccc(C(=O)NNc2c(Cl)cc(C(F)(F)F)cc2Cl)cc1

nearest known ligand 0.49

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
DDR1 Q08345 2/20 0.49
RXFP1 Q9HBX9 1/20 0.47
MRGPRX4 Q96LA9 4/20 0.46
GAA P10253 1/20 0.45
MLYCD O95822 1/20 0.44
VNN1 O95497 1/20 0.44
MAOA P21397 1/20 0.43
MAOB P27338 1/20 0.43
TMPRSS4 Q9NRS4 1/20 0.43
KIF11 P52732 1/20 0.42
TRPM8 Q7Z2W7 1/20 0.40
TRPA1 O75762 1/20 0.40
EPHX2 P34913 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8208248 0.79 GAA (0.56) RXFP1GAATMPRSS4
SCHEMBL7744114 0.74 KIF11 (0.39) RXFP1MRGPRX4MLYCDVNN1TMPRSS4
SCHEMBL7744112 0.74 KIF11 (0.39) RXFP1MRGPRX4MLYCDVNN1TMPRSS4
SCHEMBL26225890 0.74 DDR1 (0.49) DDR1RXFP1MRGPRX4GAAMLYCD
SCHEMBL7736234 0.73 RAPGEF3 (0.38) DDR1RXFP1MRGPRX4MLYCDVNN1
SCHEMBL7736233 0.73 RAPGEF3 (0.38) DDR1RXFP1MRGPRX4MLYCDVNN1
SCHEMBL26227590 0.72 CYP1A2 (0.55) DDR1RXFP1GAATRPA1
SCHEMBL26229218 0.72 DDR1 (0.47) DDR1RXFP1MRGPRX4GAATMPRSS4
SCHEMBL26229217 0.72 DDR1 (0.67) DDR1RXFP1GAATMPRSS4TRPA1
SCHEMBL26229219 0.71 DDR1 (0.46) DDR1GAATRPA1EPHX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6417386-B2 HYDRAZONE DERIVATIVES; ACARINA; MITICIDES SYNGENTA CROP PROTECTION, INC. 2002-07-09 US disclosed
US-20010039247-A1 Pesticidal compositions KARRER FRIEDRICH (CH) 2001-11-08 US disclosed
US-6306798-B1 Compounds for controlling insects and representatives of the order acarina SYNGENTA CROP PROTECTION, INC. 2001-10-23 US disclosed
EP-1021398-A1 PESTICIDAL COMPOSITIONS Novartis AG (CH) 2000-07-26 EP disclosed
WO-1998003475-A1 PESTICIDAL COMPOSITIONS NOVARTIS AG (CH) 1998-01-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010039247-A1 Pesticidal compositions MTX1, PEF1, ECH1 DDR1 4414/4885RXFP1 584/4885MRGPRX4 2819/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.