Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NMBR | P28336 | 11/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | TACR1 | P25103 | 2/20 | 0.56 |
| ▸ | TACR3 | P29371 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.53 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.53 |
| ▸ | TERT | O14746 | 1/20 | 0.52 |
| ▸ | CTSL | P07711 | 1/20 | 0.51 |
| ▸ | CTSS | P25774 | 1/20 | 0.51 |
| ▸ | CTSK | P43235 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6305891 | 0.89 | MAPT (0.76) | NMBRMAPTLMNAGAAHTT | |
| SCHEMBL8815278 | 0.85 | TACR3 (0.61) | NMBRMAPTLMNAGAAHTT | |
| SCHEMBL6020516 | 0.84 | CTSL (0.72) | NMBRMAPTLMNAGAAHTT | |
| SCHEMBL7745574 | 0.84 | CTSL (0.72) | MAPTLMNAGAAHTTTACR1 | |
| SCHEMBL6020210 | 0.84 | NMBR (0.66) | NMBRMAPTLMNAGAAHTT | |
| SCHEMBL8797226 | 0.83 | NMBR (0.70) | NMBRTACR1TACR3HDAC3HDAC1 | |
| SCHEMBL3820631 | 0.83 | KCNA5 (0.63) | NMBRHTT | |
| SCHEMBL8785114 | 0.83 | KCNA5 (0.63) | NMBRHTT | |
| SCHEMBL4612012 | 0.83 | KCNA5 (0.63) | NMBRHTT | |
| SCHEMBL8547809 | 0.83 | KMT2A (0.66) | NMBRMAPTTACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0819005-A4 | 2-ACYLAMINOPROPANAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2001-03-21 | — | — | EP | disclosed |
| EP-0819005-A1 | 2-ACYLAMINOPROPANAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1998-01-21 | — | — | EP | disclosed |
| WO-1997006803-A1 | 2-ACYLAMINOPROPANAMIDES AS GROWTH HORMONE SECRETAGOGUES | ELI LILLY AND COMPANY (US) | 1997-02-27 | — | — | WO | disclosed |
| WO-1996031214-A1 | 2-ACYLAMINOPROPANAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-10-10 | — | — | WO | disclosed |