Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 4/20 | 0.72 |
| ▸ | CTSS | P25774 | 1/20 | 0.72 |
| ▸ | CTSK | P43235 | 1/20 | 0.72 |
| ▸ | MAPT | P10636 | 4/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.63 |
| ▸ | TACR1 | P25103 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | TERT | O14746 | 2/20 | 0.59 |
| ▸ | BCHE | P06276 | 1/20 | 0.57 |
| ▸ | ACHE | P22303 | 1/20 | 0.57 |
| ▸ | CCKBR | P32239 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | ACE | P12821 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8482130 | 0.90 | CTSL (0.73) | CTSLCTSSCTSKMAPTTP53 | |
| SCHEMBL6299745 | 0.89 | TACR1 (0.75) | CTSLCTSSCTSKMAPTTP53 | |
| SCHEMBL9834534 | 0.88 | CTSL (0.80) | CTSLCTSSCTSKMAPTTP53 | |
| SCHEMBL17807348 | 0.86 | CTSL (0.80) | CTSLCTSSCTSKMAPTTP53 | |
| SCHEMBL8815278 | 0.85 | TACR3 (0.61) | CTSLCTSSCTSKMAPTTACR1 | |
| SCHEMBL8271104 | 0.85 | CTSL (0.72) | CTSLCTSSCTSKMAPTTP53 | |
| SCHEMBL8395025 | 0.85 | CTSL (0.72) | CTSLCTSSCTSKMAPTTP53 | |
| SCHEMBL7743161 | 0.84 | NMBR (0.61) | CTSLCTSSCTSKMAPTTACR1 | |
| SCHEMBL21269082 | 0.84 | CTSL (0.77) | CTSLCTSSCTSKMAPTTP53 | |
| SCHEMBL21286953 | 0.84 | CTSL (0.77) | CTSLCTSSCTSKMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0819005-A4 | 2-ACYLAMINOPROPANAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2001-03-21 | — | — | EP | disclosed |
| US-5792760-A | USEFUL IN TREATMENT OF PSYCHOLOGICAL AND CENTRAL NERVOUS SYSTEM DISORDERS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| US-5773441-A | PRODRUGS; ANIMAL HUSBANDRY | ELI LILLY AND COMPANY (US) | 1998-06-30 | — | — | US | disclosed |
| EP-0819005-A1 | 2-ACYLAMINOPROPANAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1998-01-21 | — | — | EP | disclosed |
| EP-0761220-A1 | 2-Acylaminopropanamides as growth hormone secretagogues | ELI LILLY AND COMPANY (US) | 1997-03-12 | — | — | EP | disclosed |
| US-5565568-A | USEFUL IN TREATMENT OR PREVENTION OF A PHYSIOLOGICAL DISORDER ASSOCIATED WITH AN EXCESS OF TACHYKININS | ELI LILLY AND COMPANY (US) | 1996-10-15 | — | — | US | disclosed |
| WO-1996031214-A1 | 2-ACYLAMINOPROPANAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-10-10 | — | — | WO | disclosed |