SCHEMBL7743343

SCHEMBL7743343

COc1ccc2scc3c2c1CCC3CNC(=O)NC1CCC1

nearest known ligand 0.48

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
MTNR1A P48039 17/20 0.48
MTNR1B P49286 17/20 0.48
MEN1 O00255 1/20 0.44
EPHX1 P07099 1/20 0.44
KMT2A Q03164 1/20 0.44
RAB9A P51151 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7740254 0.81 MTNR1B (0.74) MTNR1AMTNR1B
SCHEMBL7743365 0.75 HTR1A (0.43) MTNR1AMTNR1B
SCHEMBL7735721 0.74 MTNR1A (0.45) MTNR1AMTNR1B
SCHEMBL7741217 0.70 MTNR1A (0.39) MTNR1AMTNR1B
SCHEMBL7743369 0.69 NR1I2 (0.40) MTNR1AMTNR1BMEN1KMT2A
SCHEMBL6634020 0.65 MTNR1A (1.00) MTNR1AMTNR1B
SCHEMBL7735692 0.65 MTNR1A (1.00) MTNR1AMTNR1B
SCHEMBL7735727 0.65 MTNR1A (0.65) MTNR1AMTNR1B
SCHEMBL6634613 0.64 MTNR1A (1.00) MTNR1AMTNR1B
SCHEMBL6635179 0.64 MTNR1B (1.00) MTNR1AMTNR1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6423870-B1 ANTICOAGULANTS; CIRCADIAN RHYTHM DISORDERS; SLEEP DISORDERS LES LABORATOIRES SERVIER (FR) 2002-07-23 US disclosed