Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABHD6 | Q9BV23 | 4/20 | 0.54 |
| ▸ | ESR1 | P03372 | 4/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.43 |
| ▸ | HSD17B3 | P37058 | 3/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.40 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | CCR2 | P41597 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7745997 | 0.84 | NR1H2 (0.54) | ABHD6ESR1ESR2HSD17B3NR1H2 | |
| SCHEMBL7738236 | 0.84 | ESR2 (0.43) | ABHD6ESR1ESR2AKR1C3NR1H2 | |
| SCHEMBL7738183 | 0.80 | DRD2 (0.45) | ESR1ESR2AKR1C3 | |
| SCHEMBL7743587 | 0.77 | ABHD6 (0.55) | ABHD6AKR1C3CARM1 | |
| SCHEMBL29163078 | 0.76 | ABHD6 (0.39) | ABHD6HSD17B3 | |
| SCHEMBL585650 | 0.76 | ESR1 (0.72) | ABHD6ESR1ESR2HSD17B3AKR1C3 | |
| SCHEMBL30411956 | 0.76 | ESR1 (0.72) | ABHD6ESR1ESR2HSD17B3AKR1C3 | |
| SCHEMBL28369216 | 0.73 | ABHD6 (0.51) | ABHD6ESR1ESR2HSD17B3AKR1C3 | |
| SCHEMBL27737506 | 0.73 | ABHD6 (0.46) | ABHD6ESR2HSD17B3AKR1C3CARM1 | |
| SCHEMBL1787936 | 0.73 | ABHD6 (0.60) | ABHD6ESR1ESR2HSD17B3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045843-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-10-24 | — | — | EP | disclosed |
| EP-1045843-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2000-10-25 | — | — | EP | disclosed |
| US-5977134-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-11-02 | — | — | US | disclosed |
| WO-1999028313-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1999-06-10 | — | — | WO | disclosed |