Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPB2 | Q96IY4 | 11/20 | 0.50 |
| ▸ | CPA1 | P15085 | 1/20 | 0.44 |
| ▸ | CPB1 | P15086 | 3/20 | 0.42 |
| ▸ | DAO | P14920 | 2/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7743898 | 0.88 | CPB2 (0.62) | CPB2CPA1CPB1DAOCYP19A1 | |
| SCHEMBL7743300 | 0.85 | CPB2 (0.48) | CPB2CPA1CPB1DAOCYP11B2 | |
| SCHEMBL7704747 | 0.75 | CACNA1H (0.40) | CPB2DAOCYP11B2CYP11B1CYP19A1 | |
| SCHEMBL7053727 | 0.69 | CPA1 (0.71) | CPB2CPA1CPB1CYP19A1 | |
| Hydrochloric Acid SCHEMBL8495732 | 0.69 | CPA1 (0.69) | CPB2CPA1CPB1CYP19A1 | |
| SCHEMBL7704752 | 0.67 | DAO (0.40) | DAOCYP11B2CYP11B1CACNA1H | |
| SCHEMBL8865742 | 0.67 | CPA1 (0.76) | CPB2CPA1CPB1CYP19A1 | |
| SCHEMBL25220822 | 0.67 | TRPV4 (0.45) | DAOCYP11B2CYP11B1CACNA1H | |
| SCHEMBL2722813 | 0.66 | TRPV4 (0.47) | DAOCYP11B2CYP11B1CACNA1H | |
| SCHEMBL7086614 | 0.66 | CPA1 (0.51) | CPB2CPA1CPB1CYP11B2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1091736-A4 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-10-24 | — | — | EP | disclosed |
| EP-1091736-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2001-04-18 | — | — | EP | disclosed |
| WO-2000001382-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2000-01-13 | — | — | WO | disclosed |