Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | HPGDS | O60760 | 1/20 | 0.43 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25532665 | 0.86 | CHRM1 (0.45) | L3MBTL1LMNAMAPTTDP1HPGDS | |
| SCHEMBL4103688 | 0.80 | HPGDS (0.63) | HPGDSSLC16A3CNR2CYP1A2ALDH1A1 | |
| SCHEMBL7391883 | 0.78 | PTPN1 (0.65) | L3MBTL1LMNAMAPTTDP1HDAC8 | |
| SCHEMBL14124751 | 0.78 | KMT2A (0.56) | LMNAMAPTTDP1HPGDSSLC16A3 | |
| SCHEMBL7389358 | 0.76 | PTPN1 (0.67) | L3MBTL1LMNAMAPTTDP1HDAC8 | |
| SCHEMBL15587623 | 0.75 | CYP1A2 (0.50) | L3MBTL1MAPTHPGDSSLC16A3CNR2 | |
| SCHEMBL7390559 | 0.75 | HSD11B1 (0.46) | HDAC8HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL7392527 | 0.72 | LMNA (0.61) | LMNAMAPTHDAC1HDAC3HDAC2 | |
| SCHEMBL7381802 | 0.72 | LMNA (0.61) | LMNAMAPTHDAC1HDAC3HDAC2 | |
| SCHEMBL11596220 | 0.72 | CYP1A2 (0.46) | LMNAMAPTHPGDSSLC16A3CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6417192-B1 | DRUGS WITH PYRIMIDONE COMPOUNDS INHIBITORS OF THE ENZYME LDL PLA.SUB.2 AND THEREFORE OF USE IN TREATING ATHEROSCLEROSIS. | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-07-09 | — | — | US | disclosed |