SCHEMBL7744105

SCHEMBL7744105

CCOc1cncc(C(C)=CCCN)c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP11B1 P15538 2/20 0.40
CYP11B2 P19099 2/20 0.40
CHRNB2 P17787 2/20 0.40
CHRNA4 P43681 2/20 0.40
CHRNB4 P30926 1/20 0.40
CHRNA3 P32297 1/20 0.40
CHRNA7 P36544 1/20 0.40
AOC3 Q16853 2/20 0.35
SIRT2 Q8IXJ6 1/20 0.34
SIRT3 Q9NTG7 1/20 0.34
AKT1 P31749 3/20 0.33
CHUK O15111 1/20 0.33
DYRK3 O43781 1/20 0.33
ROCK2 O75116 1/20 0.33
RPS6KA5 O75582 1/20 0.33
PRKD3 O94806 1/20 0.33
MAP4K4 O95819 1/20 0.33
PIM1 P11309 1/20 0.33
PHKG2 P15735 1/20 0.33
PRKACA P17612 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5406058 0.85 MKNK2 (0.38) CYP11B1CYP11B2ROCK2MAP4K4PRKACA
SCHEMBL4242135 0.81 CHRNB2 (0.36) CYP11B1CYP11B2CHRNB2CHRNA4CHRNB4
SCHEMBL8590780 0.77 KDM4E (0.44) LMNAKMT2A
SCHEMBL5196886 0.74 AOC3 (0.34) AOC3
SCHEMBL7738084 0.73 TBXAS1 (0.38)
SCHEMBL9448534 0.72 PARP10 (0.56) SIRT2SIRT3TSHR
SCHEMBL4960002 0.71 CHRNB2 (0.70) CYP11B1CYP11B2CHRNB2CHRNA4CHRNB4
SCHEMBL14260770 0.70 CYP2C9 (0.60) LMNAKMT2A
SCHEMBL31530613 0.70 KDM4E (0.58) SIRT2SIRT3TSHRLMNAKMT2A
SCHEMBL3819558 0.70 CYP11B1 (0.51) CYP11B1CYP11B2CHRNB2CHRNA4CHRNB4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1011672-A4 COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR ELICITING ANALGESIC EFFECTS UNIV VIRGINIA COMMONWEALTH (US) 2001-04-04 EP disclosed
EP-1011672-A1 COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR ELICITING ANALGESIC EFFECTS VIRGINIA COMMONWEALTH UNIVERSITY (US) 2000-06-28 EP disclosed
EP-0873050-A4 PHARMACEUTICAL COMPOSITIONS FOR PREVENTION AND TREATMENT OF ULCERATIVE COLITIS REYNOLDS TOBACCO CO R (US) 1999-09-22 EP disclosed
WO-1999007369-A1 COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR ELICITING ANALGESIC EFFECTS VIRGINIA COMMONWEALTH UNIVERSITY (US) 1999-02-18 WO disclosed
EP-0873050-A1 PHARMACEUTICAL COMPOSITIONS FOR PREVENTION AND TREATMENT OF ULCERATIVE COLITIS R.J. REYNOLDS TOBACCO COMPANY (US) 1998-10-28 EP disclosed
EP-0801646-A4 PHARMACEUTICAL COMPOSITIONS FOR PREVENTION AND TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS REYNOLDS TOBACCO CO R (US) 1998-03-25 EP disclosed
EP-0801646-A1 PHARMACEUTICAL COMPOSITIONS FOR PREVENTION AND TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS R.J. REYNOLDS TOBACCO COMPANY (US) 1997-10-22 EP disclosed
WO-1996020929-A1 PHARMACEUTICAL COMPOSITIONS FOR PREVENTION AND TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS R.J. REYNOLDS TOBACCO COMPANY (US) 1996-07-11 WO disclosed
WO-1996020599-A1 PHARMACEUTICAL COMPOSITIONS FOR PREVENTION AND TREATMENT OF ULCERATIVE COLITIS R.J. REYNOLDS TOBACCO COMPANY (US) 1996-07-11 WO disclosed