Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.36 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7744105 | 0.85 | CYP11B1 (0.40) | MKNK2CYP11B1CYP11B2MAP4K4ROCK2 | |
| SCHEMBL8590780 | 0.80 | KDM4E (0.44) | TBXAS1 | |
| SCHEMBL365734 | 0.79 | MKNK2 (0.37) | MKNK2MKNK1CYP11B1CYP11B2MAP4K4 | |
| SCHEMBL7071083 | 0.78 | MKNK2 (0.35) | MKNK2MKNK1CYP11B1CYP11B2MAP4K4 | |
| SCHEMBL7738084 | 0.75 | TBXAS1 (0.38) | TBXAS1 | |
| SCHEMBL5196886 | 0.74 | AOC3 (0.34) | TBXAS1 | |
| SCHEMBL7238664 | 0.71 | MKNK1 (0.49) | MKNK2MKNK1CYP11B1CYP11B2MAP4K4 | |
| SCHEMBL3956347 | 0.71 | MKNK1 (0.33) | MKNK2MKNK1 | |
| Hydrochloric Acid SCHEMBL7240593 | 0.70 | MKNK1 (0.48) | MKNK2MKNK1CYP11B1CYP11B2MAP4K4 | |
| SCHEMBL3128200 | 0.70 | TBXAS1 (0.61) | CYP1A2CYP3A4TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-3899126-B2 | — | — | 2007-03-28 | — | — | JP | claimed |
| JP-2001520628-A | — | — | 2001-10-30 | — | — | JP | claimed |
| EP-0801527-A4 | PHARMACEUTICAL COMPOSITIONS FOR PREVENTION AND TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | REYNOLDS TOBACCO CO R (US) | 2001-09-05 | — | — | EP | claimed |
| EP-0801527-A1 | PHARMACEUTICAL COMPOSITIONS FOR PREVENTION AND TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | R.J. REYNOLDS TOBACCO COMPANY (US) | 1997-10-22 | — | — | EP | claimed |
| WO-1996020600-A1 | PHARMACEUTICAL COMPOSITIONS FOR PREVENTION AND TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | R.J. REYNOLDS TOBACCO COMPANY (US) | 1996-07-11 | — | — | WO | claimed |