Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | CCKBR | P32239 | 7/20 | 0.42 |
| ▸ | CCKAR | P32238 | 3/20 | 0.42 |
| ▸ | NOTCH1 | P46531 | 2/20 | 0.38 |
| ▸ | NOTCH3 | Q9UM47 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7744132 | 1.00 | KCNH2 (0.45) | KCNH2CCKBRCCKARNOTCH1NOTCH3 | |
| SCHEMBL7744120 | 0.87 | KCNH2 (0.36) | KCNH2CCKBRCCKARPSEN1PSEN2 | |
| SCHEMBL7743995 | 0.87 | KCNH2 (0.36) | KCNH2CCKBRCCKARPSEN1PSEN2 | |
| SCHEMBL7738908 | 0.78 | KCNH2 (0.45) | KCNH2CCKBRCCKARNOTCH1NOTCH3 | |
| SCHEMBL7744593 | 0.77 | KCNH2 (0.72) | KCNH2CCKBRCCKARNOTCH1NOTCH3 | |
| SCHEMBL7744135 | 0.77 | KCNH2 (0.72) | KCNH2CCKBRCCKARNOTCH1NOTCH3 | |
| SCHEMBL7744126 | 0.73 | CCKBR (0.42) | KCNH2CCKBRCCKAR | |
| SCHEMBL7212287 | 0.72 | KCNH2 (0.51) | KCNH2 | |
| SCHEMBL7744137 | 0.70 | KCNH2 (0.36) | KCNH2CCKBRCCKARNOTCH1NOTCH3 | |
| SCHEMBL8760273 | 0.69 | KCNH2 (0.75) | KCNH2CCKBRCCKARNOTCH1NOTCH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001010216-A1 | ANTIARRHYTHMIC COMPOUNDS | MERCK & CO., INC. (US) | 2001-02-15 | — | — | WO | claimed |