Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.35 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.33 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7744784 | 0.95 | SMN1; SMN2 (0.34) | CASP1HSD17B10ALDH1A1MEN1BRCA1 | |
| SCHEMBL11826001 | 0.88 | CASP1 (0.47) | CASP1HSD17B10ALDH1A1LMNAHPGD | |
| SCHEMBL7744791 | 0.87 | HSD17B10 (0.41) | CASP1HSD17B10ALDH1A1KMT2AMAPT | |
| SCHEMBL6997987 | 0.87 | MAPT (0.36) | HSD17B10ALDH1A1MAPTHPGDTSHR | |
| SCHEMBL7749356 | 0.84 | MAPT (0.38) | CASP1HSD17B10ALDH1A1MEN1KMT2A | |
| SCHEMBL7744793 | 0.82 | HSD17B10 (0.38) | CASP1HSD17B10ALDH1A1KMT2AMAPT | |
| SCHEMBL7750623 | 0.82 | SMN1; SMN2 (0.39) | CASP1HSD17B10ALDH1A1KMT2AMAPT | |
| SCHEMBL7752046 | 0.81 | RORC (0.36) | CASP1HSD17B10ALDH1A1KMT2AMAPT | |
| SCHEMBL11819756 | 0.81 | ESR1 (0.48) | CASP1HSD17B10ALDH1A1MEN1KMT2A | |
| SCHEMBL7749384 | 0.81 | KCNN4 (0.41) | CASP1HSD17B10ALDH1A1TSHRESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242607-B1 | SUCH AS 4-CYANO-4-(3,4-DICHLOROPHENYL)HEPTANEDIOIC ACID USED AS ANTAGONISTS OF NEUROKININES | SANOFI-SYNTHELABO (FR) | 2001-06-05 | — | — | US | disclosed |
| US-6008360-A | Substituted 3-aryl-3-carboxyalkyl glutaramides, method for preparing same by 4-arylo-4-cyanoheptane dicarboxylic acid cyclisation, and use thereof for preparing 3-aryl-3-hydroxyalkylpiperidines | SANOFI-SYNTHELABO (FR) | 1999-12-28 | — | — | US | disclosed |