Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | APEX1 | P27695 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 6/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 5/20 | 0.47 |
| ▸ | RAB9A | P51151 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | PLAU | P00749 | 1/20 | 0.45 |
| ▸ | ELANE | P08246 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8508742 | 0.88 | POLB (0.43) | POLBAPEX1HPGDMAPTTSHR | |
| SCHEMBL8507770 | 0.84 | POLB (0.43) | POLBAPEX1HPGDMAPTTSHR | |
| SCHEMBL8055152 | 0.83 | POLB (0.55) | POLBAPEX1HPGDMAPTTSHR | |
| SCHEMBL10960763 | 0.82 | CES2 (0.40) | POLBAPEX1HPGDMAPTTSHR | |
| SCHEMBL32668944 | 0.81 | KEAP1 (0.55) | POLBAPEX1HPGDMAPTTSHR | |
| SCHEMBL979056 | 0.81 | KEAP1 (0.55) | POLBAPEX1HPGDMAPTTSHR | |
| SCHEMBL3820327 | 0.81 | POLB (0.53) | POLBAPEX1HPGDMAPTTSHR | |
| Hydrochloric Acid SCHEMBL9488278 | 0.79 | KEAP1 (0.53) | POLBAPEX1HPGDMAPTTSHR | |
| SCHEMBL3333144 | 0.79 | POLB (0.52) | POLBAPEX1HPGDMAPTTSHR | |
| SCHEMBL3621616 | 0.79 | POLB (0.56) | POLBAPEX1HPGDMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5859298-A | REACTING 2,4-DICHLORO-5-FLUORO-BENZOYL CHLORIDE WITH POTASSIUM FLUORIDE IN AN APROTIC SOLVENT; DISTILLATION | BAYER AKTIENGESELLSCHAFT (DE) | 1999-01-12 | — | — | US | claimed |
| EP-0673912-B1 | Process for preparing 2-halogeno-4,5-difluoro-benzofluorides | BAYER AG (DE) | 1998-12-23 | — | — | EP | claimed |
| US-4994610-A | Process for preparing fluorinated benzoyl compounds | ASAHI GLASS COMPANY, LTD. (JP) | 1991-02-19 | — | — | US | claimed |
| EP-0303291-A2 | Fluorinated benzoyl compounds | ASAHI GLASS COMPANY LTD. (JP) | 1989-02-15 | — | — | EP | claimed |
| JP-8291109-A | — | — | None | — | — | JP | disclosed |
| US-11174266-B2 | Efficient process for the preparation of sitagliptin | F.I.S.—Fabbrica Italiana Sintetici S.p.A. (IT) | 2021-11-16 | — | — | US | disclosed |
| US-20210061808-A1 | NEW EFFICIENT PROCESS FOR THE PREPARATION OF SITAGLIPTIN | F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2021-03-04 | — | — | US | disclosed |
| WO-2019158285-A1 | NEW EFFICIENT PROCESS FOR THE PREPARATION OF SITAGLIPTIN. | F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2019-08-22 | — | — | WO | disclosed |
| EP-3524605-A1 | NEW EFFICIENT PROCESS FOR THE PREPARATION OF SITAGLIPTIN | F.I.S.- Fabbrica Italiana Sintetici S.p.A. (IT) | 2019-08-14 | — | — | EP | disclosed |
| EP-0781757-B1 | Process for the preparation of fluorinated benzoic acids | ABBOTT LAB (US) | 2001-01-03 | — | — | EP | disclosed |
| US-5859298-A | REACTING 2,4-DICHLORO-5-FLUORO-BENZOYL CHLORIDE WITH POTASSIUM FLUORIDE IN AN APROTIC SOLVENT; DISTILLATION | BAYER AKTIENGESELLSCHAFT (DE) | 1999-01-12 | — | — | US | disclosed |
| EP-0673912-B1 | Process for preparing 2-halogeno-4,5-difluoro-benzofluorides | BAYER AG (DE) | 1998-12-23 | — | — | EP | disclosed |
| EP-0303291-B1 | Fluorinated benzoyl compounds | ASAHI GLASS CO LTD (JP) | 1995-04-26 | — | — | EP | disclosed |
| EP-0610384-A4 | PROCESS FOR THE PREPARATION OF FLUORINATED BENZOIC ACIDS. | ABBOTT LAB (US) | 1995-01-25 | — | — | EP | disclosed |
| EP-0610384-A1 | PROCESS FOR THE PREPARATION OF FLUORINATED BENZOIC ACIDS. | ABBOTT LAB (US) | 1994-08-17 | — | — | EP | disclosed |
| WO-1993009077-A2 | PROCESS FOR THE PREPARATION OF FLUORINATED BENZOIC ACIDS | ABBOTT LABORATORIES (US) | 1993-05-13 | — | — | WO | disclosed |
| US-5093515-A | Intermediate for quinolone carboxylic acid bactericide | ASAHI GLASS COMPANY LTD. (JP) | 1992-03-03 | — | — | US | disclosed |
| US-5068449-A | FLUORINATED BENZOYL COMPOUNDS | ASAHI GLASS COMPANY, LTD. (JP) | 1991-11-26 | — | — | US | disclosed |
| US-4994610-A | Process for preparing fluorinated benzoyl compounds | ASAHI GLASS COMPANY, LTD. (JP) | 1991-02-19 | — | — | US | disclosed |
| EP-0303291-A2 | Fluorinated benzoyl compounds | ASAHI GLASS COMPANY LTD. (JP) | 1989-02-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210061808-A1 | NEW EFFICIENT PROCESS FOR THE PREPARATION OF SITAGLIPTIN | DPP4, DPP9, DPP7 | POLB 3623/4885APEX1 4120/4885HPGD 4157/4885 |
| US-11174266-B2 | Efficient process for the preparation of sitagliptin | DPP4, DPP9, DPP7 | POLB 3595/4885APEX1 4122/4885HPGD 4036/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.