Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 2/20 | 0.80 |
| ▸ | CTSS | P25774 | 1/20 | 0.80 |
| ▸ | CTSK | P43235 | 1/20 | 0.80 |
| ▸ | MAPT | P10636 | 4/20 | 0.70 |
| ▸ | GAA | P10253 | 1/20 | 0.70 |
| ▸ | HTT | P42858 | 1/20 | 0.70 |
| ▸ | CCKBR | P32239 | 3/20 | 0.69 |
| ▸ | TP53 | P04637 | 1/20 | 0.67 |
| ▸ | ACE | P12821 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | TACR1 | P25103 | 2/20 | 0.65 |
| ▸ | NMBR | P28336 | 4/20 | 0.62 |
| ▸ | KCNT1 | Q5JUK3 | 1/20 | 0.62 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8395025 | 0.92 | CTSL (0.72) | CTSLCTSSCTSKMAPTGAA | |
| SCHEMBL8271104 | 0.92 | CTSL (0.72) | CTSLCTSSCTSKMAPTGAA | |
| SCHEMBL9833490 | 0.91 | CTSL (0.76) | CTSLCTSSCTSKMAPTCCKBR | |
| SCHEMBL27839975 | 0.91 | CTSL (0.69) | CTSLCTSSCTSKMAPTGAA | |
| SCHEMBL30375072 | 0.90 | CTSL (0.80) | CTSLCTSSCTSKMAPTCCKBR | |
| SCHEMBL17807348 | 0.90 | CTSL (0.80) | CTSLCTSSCTSKMAPTCCKBR | |
| SCHEMBL8482904 | 0.89 | MAPT (0.75) | CTSLCTSSCTSKMAPTGAA | |
| SCHEMBL8482130 | 0.89 | CTSL (0.73) | CTSLCTSSCTSKMAPTGAA | |
| SCHEMBL15220151 | 0.89 | CTSL (0.65) | CTSLCTSSCTSKMAPTGAA | |
| SCHEMBL6021511 | 0.89 | CTSS (1.00) | CTSLCTSSCTSKMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0442878-A4 | DERIVATIVES OF TRYPTOPHAN AS CCK ANTAGONISTS | — | 1991-10-23 | — | — | EP | disclosed |
| EP-0442878-A1 | DERIVATIVES OF TRYPTOPHAN AS CCK ANTAGONISTS | ABBOTT LABORATORIES (US) | 1991-08-28 | — | — | EP | disclosed |
| WO-1989010355-A1 | DERIVATIVES OF TRYPTOPHAN AS CCK ANTAGONISTS | ABBOTT LABORATORIES (US) | 1989-11-02 | — | — | WO | disclosed |
| EP-0336356-A2 | Derivatives of tryptophan as CCK antagonists | ABBOTT LABORATORIES (US) | 1989-10-11 | — | — | EP | disclosed |