Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GNRHR | P30968 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7746533 | 0.77 | TDP1 (0.56) | TDP1TSHRKDM4EALDH1A1HPGD | |
| SCHEMBL7745926 | 0.73 | TDP1 (0.51) | TDP1KDM4EALDH1A1HPGDNPSR1 | |
| SCHEMBL7115198 | 0.72 | TDP1 (0.55) | TDP1TSHRKDM4ENPC1LMNA | |
| SCHEMBL7746888 | 0.71 | TDP1 (0.45) | TDP1TSHRMAPTKDM4EALDH1A1 | |
| SCHEMBL11198565 | 0.69 | TDP1 (0.61) | TDP1POLBTSHRMAPTKDM4E | |
| SCHEMBL3238812 | 0.69 | CHRM1 (0.57) | TDP1POLBLMNASMN1; SMN2GNRHR | |
| SCHEMBL3238752 | 0.69 | TDP1 (0.50) | TDP1TP53MAPTKDM4EALDH1A1 | |
| SCHEMBL1481951 | 0.66 | LMNA (0.48) | TDP1TSHRMAPTKDM4EALDH1A1 | |
| SCHEMBL17338593 | 0.65 | NPC1 (0.63) | TDP1TP53MAPTALDH1A1NPSR1 | |
| SCHEMBL8689497 | 0.65 | L3MBTL1 (0.63) | TDP1TP53POLBTSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6774134-B2 | FOR THERAPY OF RESPIRATORY SYNCYTIAL VIRUS INFECTION | BRISTOL-MYERS SQUIBB COMPANY | 2004-08-10 | — | — | US | disclosed |
| US-6774134-B2 | FOR THERAPY OF RESPIRATORY SYNCYTIAL VIRUS INFECTION | BRISTOL-MYERS SQUIBB COMPANY | 2004-08-10 | — | — | US | disclosed |