Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 11/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8734433 | 1.00 | KIF11 (0.44) | KIF11KCNH2KDM4EALOX15TDP1 | |
| SCHEMBL4579061 | 1.00 | KIF11 (0.44) | KIF11KCNH2KDM4EALOX15TDP1 | |
| SCHEMBL8403280 | 0.88 | KIF11 (0.48) | KIF11KCNH2LMNAHTTSMN1; SMN2 | |
| SCHEMBL5023008 | 0.88 | KIF11 (0.56) | KIF11KCNH2 | |
| SCHEMBL11290864 | 0.87 | KDM4E (0.33) | KIF11KDM4ELMNAKMT2AMEN1 | |
| SCHEMBL5065127 | 0.84 | KIF11 (0.45) | KIF11KCNH2LMNAHTTSMN1; SMN2 | |
| SCHEMBL3496480 | 0.82 | KIF11 (0.54) | KIF11KCNH2LMNAHTTSMN1; SMN2 | |
| SCHEMBL10586379 | 0.81 | KIF11 (0.54) | KIF11KCNH2SMN1; SMN2 | |
| SCHEMBL8734430 | 0.81 | NR3C2 (0.37) | KDM4ELMNAHTTSMN1; SMN2KMT2A | |
| SCHEMBL8080069 | 0.79 | KIF11 (0.51) | KIF11KCNH2HTTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0556301-B1 | INCORPORATION OF MULTIPLE REPORTER GROUPS ON SYNTHETIC OLIGONUCLEOTIDES | HYBRIDON INC (US) | 2001-01-10 | — | — | EP | disclosed |
| US-5510475-A | ATTACHMENT OF REPORTERS BY WAY OF PHOSPHONAMIDATE LINKERS, HAVING PROTECTED HYDROXYL OR AMINO FUNCTIONALITY | HYBRIDON, INC. (US) | 1996-04-23 | — | — | US | disclosed |
| EP-0556301-A1 | INCORPORATION OF MULTIPLE REPORTER GROUPS ON SYNTHETIC OLIGONUCLEOTIDES | HYBRIDON, Inc. (US) | 1993-08-25 | — | — | EP | disclosed |
| WO-1992008728-A1 | INCORPORATION OF MULTIPLE REPORTER GROUPS ON SYNTHETIC OLIGONUCLEOTIDES | HYBRIDON, INC. (US) | 1992-05-29 | — | — | WO | disclosed |