SCHEMBL5023008

SCHEMBL5023008

COc1ccc(C(c2ccccc2)(c2ccc(OC)cc2)C(O)CCCCCN)cc1

nearest known ligand 0.56

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 13/20 0.56
KCNH2 Q12809 1/20 0.56
SLC7A5 Q01650 4/20 0.45
ALDH1A1 P00352 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10586379 0.89 KIF11 (0.54) KIF11KCNH2ALDH1A1
SCHEMBL4579061 0.88 KIF11 (0.44) KIF11KCNH2
SCHEMBL8734433 0.88 KIF11 (0.44) KIF11KCNH2
SCHEMBL7747362 0.88 KIF11 (0.44) KIF11KCNH2
SCHEMBL3475085 0.85 KIF11 (0.57) KIF11KCNH2SLC7A5ALDH1A1
SCHEMBL1040140 0.85 KIF11 (0.57) KIF11KCNH2SLC7A5ALDH1A1
SCHEMBL5065127 0.83 KIF11 (0.45) KIF11KCNH2
SCHEMBL3617563 0.82 ALDH1A1 (0.42) KIF11KCNH2ALDH1A1
SCHEMBL5023004 0.82 CHRM2 (0.39) KIF11KCNH2SLC7A5ALDH1A1
SCHEMBL8403280 0.81 KIF11 (0.48) KIF11KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1991552-A2 PHOSPHONYLATED FLUORESCENT DYES AND CONJUGATES Epoch Biosciences, Inc. (US) 2008-11-19 EP disclosed
US-7329515-B2 Solid support for the synthesis of 3′-amino oligonucleotides SIGMA-ALDRICH CO. (US) 2008-02-12 US disclosed
WO-2007098182-A2 PHOSPHONYLATED FLUORESCENT DYES AND CONJUGATES EPOCH BIOSCIENCES, INC. (US) 2007-08-30 WO disclosed
EP-1781675-A2 PHOSPHONATE FLUORESCENT DYES AND CONJUGATES Epoch Biosciences, Inc. (US) 2007-05-09 EP disclosed
WO-2006020947-A2 PHOSPHONATE FLUORESCENT DYES AND CONJUGATES EPOCH BIOSCIENCES, INC. (US) 2006-02-23 WO disclosed
US-20040220397-A1 Solid support for the synthesis of 3'-amino oligonucleotides PROLIGO LLC (US) 2004-11-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040220397-A1 Solid support for the synthesis of 3'-amino oligonucleotides PCNA, DERA, RNGTT KIF11 3018/4885KCNH2 4590/4885SLC7A5 105/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.