Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 17/20 | 0.66 |
| ▸ | ESR2 | Q92731 | 17/20 | 0.66 |
| ▸ | LTA4H | P09960 | 1/20 | 0.64 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.61 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.61 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.61 |
| ▸ | GCGR | P47871 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | PLD2 | O14939 | 1/20 | 0.57 |
| ▸ | KDM1A | O60341 | 1/20 | 0.57 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | C5 | P01031 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | FYN | P06241 | 1/20 | 0.57 |
| ▸ | PGR | P06401 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3092657 | 0.94 | ESR1 (0.65) | ESR1ESR2PSMB1PSMB5PSMB2 | |
| SCHEMBL7738182 | 0.93 | ESR1 (0.64) | ESR1ESR2LTA4HPSMB1PSMB5 | |
| SCHEMBL8593768 | 0.90 | ESR1 (0.67) | ESR1ESR2PSMB1PSMB5PSMB2 | |
| SCHEMBL8708988 | 0.90 | ESR1 (0.67) | ESR1ESR2PSMB1PSMB5PSMB2 | |
| SCHEMBL8588964 | 0.88 | LTA4H (0.64) | ESR1ESR2LTA4HPSMB1PSMB5 | |
| SCHEMBL7352552 | 0.86 | LTA4H (0.65) | ESR1ESR2LTA4HPSMB1PSMB5 | |
| SCHEMBL7443174 | 0.85 | PSMB1 (0.70) | ESR1ESR2LTA4HPSMB1PSMB5 | |
| SCHEMBL7445638 | 0.83 | LTA4H (0.70) | ESR1ESR2LTA4HPSMB1PSMB5 | |
| SCHEMBL4786645 | 0.83 | KDR (0.65) | ESR1ESR2LTA4HKCNH2 | |
| SCHEMBL8599886 | 0.82 | ESR1 (0.65) | ESR1ESR2LTA4HPSMB1PSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888331-A4 | SYNTHESIS OF 3-[4-(2-AMINOETHOXY)-BENZOYL]-2-ARYL-6-HYDROXY-BENZO[b]THIOPHENES | LILLY CO ELI (US) | 2001-05-23 | — | — | EP | disclosed |
| EP-0888331-A1 | SYNTHESIS OF 3-[4-(2-AMINOETHOXY)-BENZOYL]-2-ARYL-6-HYDROXY-BENZO[b]THIOPHENES | ELI LILLY AND COMPANY (US) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997034888-A1 | SYNTHESIS OF 3-[4-(2-AMINOETHOXY)-BENZOYL]-2-ARYL-6-HYDROXY-BENZO[b]THIOPHENES | ELI LILLY AND COMPANY (US) | 1997-09-25 | — | — | WO | disclosed |