Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | AGER | Q15109 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5859680 | 0.79 | MEN1 (0.50) | CYP1A2CYP2C19CYP3A4CYP2D6SMN1; SMN2 | |
| SCHEMBL5858877 | 0.79 | CYP1A2 (0.48) | CYP1A2CYP2C19CYP3A4CYP2D6SMN1; SMN2 | |
| SCHEMBL9039161 | 0.73 | CYP1A2 (0.55) | CYP1A2CYP2C19CYP3A4CYP2D6SMN1; SMN2 | |
| SCHEMBL7746704 | 0.70 | TOP2A (0.55) | CYP2D6USP2NPSR1MAPTALDH1A1 | |
| SCHEMBL7837246 | 0.70 | SMN1; SMN2 (0.56) | CYP1A2CYP2C19SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL8034260 | 0.70 | SMN1; SMN2 (0.49) | CYP1A2CYP2C19CYP3A4CYP2D6SMN1; SMN2 | |
| SCHEMBL4873241 | 0.70 | NOD1 (0.66) | CYP1A2CYP2D6SMN1; SMN2MEN1KMT2A | |
| SCHEMBL14524222 | 0.70 | AGTR1 (0.54) | CYP1A2CYP2C19ALDH1A1KDM4EPOLB | |
| SCHEMBL16604021 | 0.69 | MAPT (0.63) | SMN1; SMN2USP2NPSR1MAPTAGER | |
| SCHEMBL3823423 | 0.68 | TSHR (0.57) | CYP1A2CYP2C19SMN1; SMN2USP2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6774134-B2 | FOR THERAPY OF RESPIRATORY SYNCYTIAL VIRUS INFECTION | BRISTOL-MYERS SQUIBB COMPANY | 2004-08-10 | — | — | US | disclosed |
| US-6774134-B2 | FOR THERAPY OF RESPIRATORY SYNCYTIAL VIRUS INFECTION | BRISTOL-MYERS SQUIBB COMPANY | 2004-08-10 | — | — | US | disclosed |