Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 3/20 | 0.43 |
| ▸ | PLD2 | O14939 | 2/20 | 0.37 |
| ▸ | PLD1 | Q13393 | 2/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 12/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 11/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 11/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7743435 | 0.93 | CCR2 (0.39) | CCR2ADRA1ATP53CYP3A4MAPT | |
| SCHEMBL7743434 | 0.93 | CCR2 (0.39) | CCR2ADRA1ATP53CYP3A4MAPT | |
| SCHEMBL7747425 | 0.77 | ADRA1A (0.49) | ADRA1AADRA1DADRA1BHRH1 | |
| SCHEMBL7675111 | 0.77 | ADRA1D (0.43) | ADRA1AADRA1DADRA1B | |
| SCHEMBL7679189 | 0.77 | ADRA1D (0.43) | ADRA1AADRA1DADRA1B | |
| SCHEMBL7679689 | 0.77 | ADRA1D (0.43) | ADRA1AADRA1DADRA1B | |
| SCHEMBL4999332 | 0.73 | CCR2 (0.49) | CCR2PLD2PLD1ADRA1ATP53 | |
| SCHEMBL4999331 | 0.73 | CCR2 (0.49) | CCR2PLD2PLD1ADRA1ATP53 | |
| SCHEMBL5663717 | 0.72 | MTOR (0.34) | ADRA1AADRA1DADRA1B | |
| SCHEMBL7678845 | 0.72 | MTOR (0.34) | ADRA1AADRA1DADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001022919-A2 | SPIRO[BICYCLIC -AZACYCLOALKYL AND -CYCLOALKYL] DERIVATIVES AND USES THEREOF | MERCK & CO., INC. (US) | 2001-04-05 | — | — | WO | claimed |