SCHEMBL7749392

SCHEMBL7749392

COc1ccc(Oc2ccc(OCCN3CCCCC3)cc2-c2ccc(OCc3ccccc3)cc2)cc1

nearest known ligand 0.61

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
LTA4H P09960 8/20 0.61
HTT P42858 1/20 0.55
KCNH2 Q12809 4/20 0.55
MCHR1 Q99705 4/20 0.55
HRH3 Q9Y5N1 1/20 0.53
NPC1 O15118 2/20 0.51
RAB9A P51151 2/20 0.51
SMN1; SMN2 Q16637 2/20 0.51
KDM4E B2RXH2 2/20 0.50
ALDH1A1 P00352 1/20 0.50
NPY1R P25929 1/20 0.50
ESR1 P03372 1/20 0.49
EBP Q15125 1/20 0.49
SIGMAR1 Q99720 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7209701 0.85 ESR1 (0.62) LTA4HESR1
SCHEMBL7778587 0.85 ESR1 (0.63) KCNH2HRH3ESR1
SCHEMBL7469979 0.83 LTA4H (0.51) LTA4HKCNH2MCHR1HRH3KDM4E
SCHEMBL4688871 0.79 LTA4H (0.97) LTA4HHTTKCNH2MCHR1HRH3
SCHEMBL20748052 0.79 LTA4H (0.97) LTA4HHTTKCNH2MCHR1HRH3
SCHEMBL7178420 0.79 ESR1 (0.76) LTA4HESR1
SCHEMBL7452788 0.78 ESR1 (0.52) KCNH2MCHR1HRH3SMN1; SMN2KDM4E
SCHEMBL7135450 0.78 LTA4H (0.81) LTA4HHTTKCNH2MCHR1HRH3
SCHEMBL2476820 0.78 LTA4H (1.00) LTA4HHTTKCNH2MCHR1HRH3
SCHEMBL7443697 0.78 LTA4H (0.54) LTA4HHTTKCNH2MCHR1HRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0975628-A4 PREVENTION OF BREAST CANCER WITH SELECTIVE ESTROGEN RECEPTOR MODULATORS LILLY CO ELI (US) 2001-03-21 EP disclosed
EP-0975628-A1 PREVENTION OF BREAST CANCER WITH SELECTIVE ESTROGEN RECEPTOR MODULATORS ELI LILLY AND COMPANY (US) 2000-02-02 EP disclosed
WO-1998045286-A1 PREVENTION OF BREAST CANCER WITH SELECTIVE ESTROGEN RECEPTOR MODULATORS ELI LILLY AND COMPANY (US) 1998-10-15 WO disclosed