Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19544761 | 0.74 | SLC6A4 (0.42) | POLBMTNR1AMTNR1BMEN1KMT2A | |
| SCHEMBL11384019 | 0.73 | MTNR1A (0.57) | MTNR1AMTNR1BMEN1KMT2AGAA | |
| SCHEMBL8652167 | 0.73 | ALDH1A1 (0.47) | POLBTDP1MEN1KMT2AALDH1A1 | |
| SCHEMBL27671316 | 0.72 | POLB (0.60) | POLBTDP1TSHRMEN1KMT2A | |
| SCHEMBL1328578 | 0.72 | GAA (0.56) | POLBMTNR1AMTNR1BTDP1TSHR | |
| SCHEMBL1684925 | 0.72 | BCAT2 (0.47) | KMT2AGAAALDH1A1LMNACYP1A2 | |
| SCHEMBL6804593 | 0.71 | ALDH1A1 (0.41) | POLBMTNR1AMTNR1BTSHRMEN1 | |
| SCHEMBL17046780 | 0.71 | POLB (0.41) | POLBMTNR1AMTNR1BMEN1KMT2A | |
| SCHEMBL7979605 | 0.71 | MTNR1A (0.47) | POLBMTNR1AMTNR1BTDP1TSHR | |
| SCHEMBL11402564 | 0.71 | MAOA (0.52) | POLBMTNR1AMTNR1BMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0568437-B1 | Antidepressant 3-Halophenylpiperazinyl-propyl Derivatives of Substituted Triazolones and Triazoldiones | BRISTOL MYERS SQUIBB CO (US) | 2001-02-21 | — | — | EP | disclosed |
| EP-0568437-A1 | Antidepressant 3-Halophenylpiperazinyl-propyl Derivatives of Substituted Triazolones and Triazoldiones | Bristol-Myers Squibb Company (US) | 1993-11-03 | — | — | EP | disclosed |
| US-5256664-A | Antidepressant 3-halophenylpiperazinylpropyl derivatives of substituted triazolones and triazoldiones | BRISTOL-MYERS SQUIBB COMPANY (US) | 1993-10-26 | — | — | US | disclosed |