Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of 2,4-Diaminophenol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 6/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.52 |
| ▸ | CA1 | P00915 | 3/20 | 0.52 |
| ▸ | CA2 | P00918 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | RECQL | P46063 | 3/20 | 0.46 |
| ▸ | CASP1 | P29466 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | THRB | P10828 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2,4-Diaminophenol SCHEMBL27284 | 0.95 | — | — | |
| 2,4-Diaminophenol SCHEMBL28147894 | 0.92 | ALDH1A1 (0.54) | ALDH1A1HSD17B10ALOX15HPGDALOX12 | |
| 2,4-Diaminophenol SCHEMBL29389205 | 0.92 | ALDH1A1 (0.54) | ALDH1A1HSD17B10ALOX15HPGDALOX12 | |
| 2,4-Diaminophenol SCHEMBL30192203 | 0.92 | ALDH1A1 (0.54) | ALDH1A1HSD17B10ALOX15HPGDALOX12 | |
| 2,4-Diaminophenol SCHEMBL1884352 | 0.92 | ALDH1A1 (0.54) | ALDH1A1HSD17B10ALOX15HPGDALOX12 | |
| 2,4-Diaminophenol SCHEMBL11222476 | 0.92 | ALDH1A1 (0.54) | ALDH1A1HSD17B10ALOX15HPGDALOX12 | |
| 2,4-Diaminophenol SCHEMBL7221197 | 0.92 | ALDH1A1 (0.54) | ALDH1A1HSD17B10ALOX15HPGDALOX12 | |
| 2,4-Diaminophenol SCHEMBL456211 | 0.92 | ALDH1A1 (0.54) | ALDH1A1HSD17B10ALOX15HPGDALOX12 | |
| 2,4-Diaminophenol SCHEMBL2382912 | 0.85 | ALDH1A1 (0.62) | ALDH1A1HSD17B10ALOX15HPGDALOX12 | |
| 2,4-Diaminophenol SCHEMBL1876910 | 0.83 | ALDH1A1 (0.61) | ALDH1A1HSD17B10ALOX15HPGDALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023284777-A1 | COPOLYMER FILM, ENZYME CATALYSIS SELF-ASSEMBLY SYNTHESIS METHOD THEREFOR, AND APPLICATION THEREOF | 中国科学院天津工业生物技术研究所 | 2023-01-19 | — | — | WO | disclosed |
| CN-115612114-A | Copolymer membrane and enzymatic self-assembly synthesis method and application thereof | 中国科学院天津工业生物技术研究所 | 2023-01-17 | — | — | CN | disclosed |
| CN-115612403-A | Self-assembly strong-adhesion copolymer film, film coating method and application | 中国科学院天津工业生物技术研究所 | 2023-01-17 | — | — | CN | disclosed |
| CN-115612699-A | Copolymer membrane and enzymatic self-assembly synthesis method and application thereof at gas-liquid interface | 中国科学院天津工业生物技术研究所 | 2023-01-17 | — | — | CN | disclosed |
| EP-1068531-A2 | LIGAND SCREENING AND DESIGN BY X-RAY CRYSTALLOGRAPHY | Abbott Laboratories (US) | 2001-01-17 | — | — | EP | disclosed |
| WO-1999045389-A2 | LIGAND SCREENING AND DESIGN BY X-RAY CRYSTALLOGRAPHY | ABBOTT LAB (US) | 1999-09-10 | — | — | WO | disclosed |
| WO-1999045379-A2 | LIGAND SCREENING AND DESIGN BY X-RAY CRYSTALLOGRAPHY | ABBOTT LABORATORIES (US) | 1999-09-10 | — | — | WO | disclosed |