2,4-Diaminophenol

2,4-Diaminophenol

SCHEMBL456211

Cl.Nc1ccc(O)c(N)c1

nearest known ligand 0.54

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of 2,4-Diaminophenol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA2 known ✓ P00918 3/20 0.54
GAA known ✓ P10253 6/20 0.52
HSP90AA1 known ✓ P07900 1/20 0.48
PTGS2 known ✓ P35354 1/20 0.48
KDR known ✓ P35968 1/20 0.48
ACHE known ✓ P22303 1/20 0.47
ALDH1A1 P00352 9/20 0.54
HSD17B10 Q99714 6/20 0.54
ALOX15 P16050 6/20 0.54
HPGD P15428 3/20 0.54
ALOX12 P18054 3/20 0.54
CA1 P00915 3/20 0.54
SMN1; SMN2 Q16637 2/20 0.54
MAPK1 P28482 2/20 0.54
PDE10A Q9Y233 1/20 0.54
MEN1 O00255 4/20 0.52
MAPT P10636 4/20 0.52
KMT2A Q03164 4/20 0.52
KDM4E B2RXH2 3/20 0.52
RECQL P46063 3/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
2,4-Diaminophenol SCHEMBL11222476 1.00 ALDH1A1 (0.54) ALDH1A1HSD17B10ALOX15HPGDALOX12
2,4-Diaminophenol SCHEMBL29389205 1.00 ALDH1A1 (0.54) ALDH1A1HSD17B10ALOX15HPGDALOX12
2,4-Diaminophenol SCHEMBL7221197 1.00 ALDH1A1 (0.54) ALDH1A1HSD17B10ALOX15HPGDALOX12
2,4-Diaminophenol SCHEMBL30192203 1.00 ALDH1A1 (0.54) ALDH1A1HSD17B10ALOX15HPGDALOX12
2,4-Diaminophenol SCHEMBL1884352 1.00 ALDH1A1 (0.54) ALDH1A1HSD17B10ALOX15HPGDALOX12
2,4-Diaminophenol SCHEMBL27284 0.97
2,4-Diaminophenol SCHEMBL28147894 0.94 ALDH1A1 (0.54) ALDH1A1HSD17B10ALOX15HPGDALOX12
2,4-Diaminophenol SCHEMBL7751374 0.92 ALDH1A1 (0.52) ALDH1A1HSD17B10ALOX15HPGDALOX12
2,4-Diaminophenol SCHEMBL2382912 0.87 ALDH1A1 (0.62) ALDH1A1HSD17B10ALOX15HPGDALOX12
2,4-Diaminophenol SCHEMBL1876910 0.85 ALDH1A1 (0.61) ALDH1A1HSD17B10ALOX15HPGDALOX12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 294 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122037919-A Water-soluble red light carbon dot, preparation method thereof and application thereof in ammonia gas detection 中国科学院兰州化学物理研究所 2026-05-15 CN claimed
CN-118978912-A Red fluorescent silicon nanoparticle for detecting ethanol and cell imaging and preparation method and application thereof 华北理工大学 2024-11-19 CN claimed
CN-118524734-A Rigid red light display device and preparation method 甘肃省科学院传感技术研究所 2024-08-20 CN claimed
CN-118450755-A Flexible red light display device and preparation method 甘肃省科学院传感技术研究所 2024-08-06 CN claimed
CN-117964572-A Preparation method of 2- (2-hydroxy-4-aminophenyl) -5-aminobenzoxazole 浙江鼎龙科技股份有限公司 2024-05-03 CN claimed
CN-115386372-B Preparation of chiral fluorescent carbon dots and application of chiral fluorescent carbon dots in identification and detection of tyrosine enantiomers 中国科学院兰州化学物理研究所 2023-05-26 CN claimed
CN-115386372-A Preparation of chiral fluorescent carbon dots and application of chiral fluorescent carbon dots in identification and detection of tyrosine enantiomers 中国科学院兰州化学物理研究所 2022-11-25 CN claimed
CN-113956871-B Preparation of silicon nanoparticles with red fluorescence and application of silicon nanoparticles in detection of acid phosphatase 中国科学院兰州化学物理研究所 2022-07-12 CN claimed
CN-113956871-A Preparation of silicon nanoparticles with red fluorescence and application of silicon nanoparticles in detection of acid phosphatase 中国科学院兰州化学物理研究所 2022-01-21 CN claimed
US-10548824-B2 Oxidative hair dying and conditioning composition and method for base breaking hair with an oxidative hair dye NUMBER THREE INC (JP) 2020-02-04 US claimed
CN-100519627-C Method of preparing polybenzoxazole-imide and its fiber UNIV HARBIN ENG (CN) 2009-07-29 CN claimed
EP-1926466-A2 STABLE EMULSION SYSTEMS WITH HIGH SALT TOLERANCE COMBE INCORPORATED (US) 2008-06-04 EP claimed
CN-101016381-A Method of preparing polybenzoxazole-imide and its fiber HARBIN INST OF TECHNOLOGY (CN) 2007-08-15 CN claimed
WO-2007040598-A2 STABLE EMULSION SYSTEMS WITH HIGH SALT TOLERANCE COMBE INCORPORATED (US) 2007-04-12 WO claimed
US-20070065390-A1 Stable emulsion systems with high salt tolerance RECKITT BENCKISER LLC 2007-03-22 US claimed
CN-1583752-A Synthesis of benzoxazole UNIV HARBIN POLYTECHNIC (CN) 2005-02-23 CN claimed
US-6702863-B1 SINGLE PACKAGE AEROSOL CONPRISED OF 5,6-DIHYDROXYINDOLINE, LACCASE, WATER AND PROPELLANT; NONIRRITATING; STORAGE STABLE LION CORPORATION (JP) 2004-03-09 US claimed
EP-0348353-A2 The use of physiologically active substances for the manufacture of drugs for cerebral and neuronal diseases NIPPON ZOKI PHARMACEUTICAL CO. LTD. (JP) 1989-12-27 EP claimed
EP-0096319-B1 METHOD FOR PREVENTING SCALE DEPOSITION IN THE POLYMERIZATION OF ETHYLENICALLY UNSATURATED MONOMERS Shin-Etsu Chemical Co., Ltd. (JP) 1986-03-26 EP claimed
EP-0096319-A1 Method for preventing scale deposition in the polymerization of ethylenically unsaturated monomers Shin-Etsu Chemical Co., Ltd. (JP) 1983-12-21 EP claimed