Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.62 |
| ▸ | MEN1 | O00255 | 4/20 | 0.62 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 11/20 | 0.60 |
| ▸ | RAB9A | P51151 | 11/20 | 0.60 |
| ▸ | CASP3 | P42574 | 3/20 | 0.60 |
| ▸ | SENP7 | Q9BQF6 | 3/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.57 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.57 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.56 |
| ▸ | NQO2 | P16083 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | PLAU | P00749 | 3/20 | 0.52 |
| ▸ | F2 | P00734 | 1/20 | 0.52 |
| ▸ | PLG | P00747 | 1/20 | 0.52 |
| ▸ | PLAT | P00750 | 1/20 | 0.52 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.52 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.52 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8537002 | 0.85 | TRPV1 (0.58) | KMT2AMEN1NR1H4NPC1RAB9A | |
| SCHEMBL15668082 | 0.83 | PGR (0.60) | KMT2AMEN1NR1H4NPC1RAB9A | |
| SCHEMBL9500132 | 0.81 | NPC1 (0.65) | KMT2AMEN1NPC1RAB9APOLB | |
| SCHEMBL9499648 | 0.81 | NPC1 (0.59) | KMT2AMEN1NPC1RAB9APOLB | |
| SCHEMBL7164864 | 0.80 | NPC1 (0.52) | KMT2AMEN1NPC1RAB9APOLB | |
| SCHEMBL9502356 | 0.80 | MAPT (0.55) | KMT2AMEN1NPC1KDM4E | |
| SCHEMBL9500932 | 0.80 | RAB9A (0.58) | KMT2AMEN1NPC1RAB9ACASP3 | |
| SCHEMBL9502383 | 0.80 | HDAC1 (0.50) | NPC1RAB9APOLBKDM4E | |
| SCHEMBL10331192 | 0.79 | CYP1A2 (0.52) | NPC1RAB9ACASP3SENP7POLB | |
| SCHEMBL7781982 | 0.79 | RAB9A (0.72) | KMT2AMEN1NR1H4NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0769015-B1 | PHOSPHONIC ACID COMPOUNDS, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2001-03-14 | — | — | EP | disclosed |
| US-5716944-A | USEFUL AS PROPHYLACTIC AND THERAPEUTIC AGENTS OF VARIOUS METABOLIC BONE DISEASES SUCH AS OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-10 | — | — | US | disclosed |
| EP-0769015-A1 | PHOSPHONIC ACID COMPOUNDS, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1997-04-23 | — | — | EP | disclosed |
| WO-1996001267-A1 | PHOSPHONIC ACID COMPOUNDS, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-01-18 | — | — | WO | disclosed |