Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 8/20 | 0.47 |
| ▸ | CCKAR | P32238 | 4/20 | 0.47 |
| ▸ | F10 | P00742 | 5/20 | 0.38 |
| ▸ | XIAP | P98170 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 3/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7752708 | 0.92 | CCKBR (0.46) | CCKBRCCKARF10XIAPCNR2 | |
| SCHEMBL8089888 | 0.81 | F10 (0.41) | CCKBRCCKARF10CNR2F2 | |
| SCHEMBL8783598 | 0.81 | ACE (0.44) | CCKBRF10 | |
| SCHEMBL8797702 | 0.79 | CCKBR (0.54) | CCKBRCCKAR | |
| SCHEMBL7752993 | 0.76 | CCKAR (0.78) | CCKBRCCKAR | |
| SCHEMBL8095747 | 0.75 | F10 (0.44) | F10CNR2F2 | |
| SCHEMBL8095859 | 0.75 | F10 (0.44) | F10CNR2F2 | |
| SCHEMBL8089998 | 0.75 | F10 (0.44) | F10CNR2F2 | |
| SCHEMBL7597322 | 0.74 | CCKBR (0.58) | CCKBRCCKAR | |
| SCHEMBL8808190 | 0.73 | MAPT (0.43) | CCKBRCCKARXIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0694039-B1 | 1,5-BENZODIAZEPINE DERIVATIVES HAVING CCK ANTAGONISTIC AND OR AGONISTIC ACTIVITY | GLAXO WELLCOME INC (US) | 2001-01-24 | — | — | EP | disclosed |
| US-5646140-A | CHOLECYSTOKININ ANTAGONIST; APETITE CONTROL | GLAXO WELLCOME INC. (US) | 1997-07-08 | — | — | US | disclosed |
| WO-1994024149-A1 | 1,5-BENZODIAZEPINE DERIVATIVES HAVING CCK ANTAGONISTIC OR AGONISTIC ACTIVITY | GLAXO INC. (US) | 1994-10-27 | — | — | WO | disclosed |