SCHEMBL7753016

SCHEMBL7753016

CC1(C)CC(C)(c2cccc(Br)c2O)Oc2ccccc21

nearest known ligand 0.39

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
FTO Q9C0B1 2/20 0.39
AKR1C1 Q04828 1/20 0.37
HSP90AA1 P07900 1/20 0.35
CRHBP P24387 1/20 0.31
CRHR2 Q13324 1/20 0.31
DHFR P00374 1/20 0.31
TYMS P04818 1/20 0.31
PRMT1 Q99873 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6912767 0.87 FTO (0.41) FTOAKR1C1HSP90AA1DHFRTYMS
SCHEMBL1838042 0.80 FTO (0.47) FTO
SCHEMBL7751772 0.77 DHFR (0.40) FTOAKR1C1HSP90AA1DHFRTYMS
SCHEMBL13450786 0.75 FTO (0.38) FTO
SCHEMBL1837301 0.75 MEN1 (0.43) FTOHSP90AA1DHFRTYMSPRMT1
SCHEMBL29525901 0.75 MEN1 (0.43) FTOHSP90AA1DHFRTYMSPRMT1
SCHEMBL7738835 0.74 FTO (0.39) FTOAKR1C1
SCHEMBL12120382 0.73 CFTR (0.37) FTO
SCHEMBL6911622 0.72 FTO (0.43) FTOAKR1C1HSP90AA1
SCHEMBL12680735 0.72 FTO (0.35) FTO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0685526-B1 Fire-resistant polycarbonate resin composition GEN ELECTRIC (US) 2001-08-29 EP disclosed
US-6197917-B1 Method for manufacturing polycarbonate for optical use GENERAL ELECTRIC COMPANY 2001-03-06 US disclosed
EP-1070743-A2 Optical polycarbonate compositions GE PLASTICS JAPAN LIMITED (JP) 2001-01-24 EP disclosed
US-6043310-A FIRE-RESISTANT POLYCARBONATE RESIN COMPOSITION CONTAINING LIQUID CRYSTAL POLYMER, FLAME RETARDANT, POLYTETRAFLUOROETHYLENE. GENERAL ELECTRIC COMPANY (US) 2000-03-28 US disclosed
EP-0561630-B1 Polycarbonate resin compositions for optical use GE PLASTICS JAPAN LTD (JP) 1999-12-29 EP disclosed
US-5883194-A RADIATION TRANSPARENT THERMOPLASTIC RESINS OF CARBONATE AND ESTER BLENDS WITH ACRYLATE RESINS AND CATALYSTS GENERAL ELECTRIC COMPANY (US) 1999-03-16 US disclosed
US-5484874-A EXHIBITING GOOD MOLD RELEASE, THERMAL STABILITY AND LITTLE DISCOLORATION DURING MOLDING GE PLASTICS, JAPAN, LTD. (JP) 1996-01-16 US disclosed
EP-0685526-A2 Fire-resistant polycarbonate resin composition GENERAL ELECTRIC COMPANY (US) 1995-12-06 EP disclosed
US-5418269-A Made by ester interchange, mold release, thermal stability, little discoloration on molding, disks GE PLASTICS JAPAN (JP) 1995-05-23 US disclosed
US-5403878-A With alpha olefin oligomer and acidic sulfur compound; mold releasing, thermostability CITIBANK, N.A., AS COLLATERAL AGENT 1995-04-04 US disclosed
US-5389713-A Polycarbonate formed by melt polymerization of aromatic dihydroxy compound and carbonate diester, alpha-olefin oligomer, acidic sulfur-containing compound GE PLASTICS JAPAN (JP) 1995-02-14 US disclosed
EP-0605157-A2 Resin compositions GE PLASTICS JAPAN LIMITED (JP) 1994-07-06 EP disclosed
EP-0605194-A2 Transparent polycarbonate-polyester-blends GE PLASTICS JAPAN LIMITED (JP) 1994-07-06 EP disclosed
US-5276109-A Molding materials with transparency GENERAL ELECTRIC COMPANY (US) 1994-01-04 US disclosed
EP-0561638-A1 Optical-grade polycarbonate resin compositions GE PLASTICS JAPAN LIMITED (JP) 1993-09-22 EP disclosed
EP-0561629-A2 Polycarbonate resin compositions GE PLASTICS JAPAN LIMITED (JP) 1993-09-22 EP disclosed
EP-0561630-A2 Polycarbonate resin compositions for optical use GE PLASTICS JAPAN LIMITED (JP) 1993-09-22 EP disclosed
EP-0520806-A2 Optical polycarbonate compositions GE PLASTICS JAPAN LIMITED (JP) 1992-12-30 EP disclosed