Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.44 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4593743 | 0.73 | CA1 (0.52) | ALDH1A1PARP10CA1CA2PARP1 | |
| SCHEMBL7753781 | 0.72 | PARP10 (0.43) | TP53LMNAKMT2AALDH1A1PARP10 | |
| SCHEMBL17292712 | 0.68 | PARP10 (0.70) | TP53LMNAKMT2AALDH1A1PARP10 | |
| SCHEMBL7736889 | 0.68 | CES2 (0.52) | TP53LMNAKMT2AALDH1A1PARP10 | |
| SCHEMBL7745401 | 0.67 | TP53 (0.43) | TP53LMNAKMT2AALDH1A1HSP90AA1 | |
| SCHEMBL2112462 | 0.66 | KDM4E (0.59) | TP53LMNAKMT2AALDH1A1PARP10 | |
| SCHEMBL10049412 | 0.66 | CA1 (0.59) | ALDH1A1PARP10CA1CA2PARP1 | |
| SCHEMBL834715 | 0.65 | TP53 (1.00) | TP53LMNAKMT2AALDH1A1HSP90AA1 | |
| SCHEMBL5830407 | 0.65 | ALDH1A1 (0.43) | KMT2AALDH1A1PARP10CA1CA2 | |
| SCHEMBL201761 | 0.65 | PARP10 (1.00) | KMT2AALDH1A1PARP10CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1070055-A1 | SUBSTITUTED PHENYL PYRIDAZINONES | Bayer Aktiengesellschaft (DE) | 2001-01-24 | — | — | EP | disclosed |
| WO-1999052878-A1 | SUBSTITUTED PHENYL PYRIDAZINONES | BAYER AKTIENGESELLSCHAFT (DE) | 1999-10-21 | — | — | WO | disclosed |