Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | CDK2 | P24941 | 1/20 | 0.54 |
| ▸ | THPO | P40225 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6546363 | 0.88 | LMNA (0.64) | LMNAALDH1A1GAAMAPTMEN1 | |
| SCHEMBL31541287 | 0.84 | MEN1 (0.52) | LMNAALDH1A1GAAMAPTMEN1 | |
| SCHEMBL11157919 | 0.84 | MEN1 (0.52) | LMNAALDH1A1GAAMAPTMEN1 | |
| SCHEMBL11883066 | 0.84 | ALDH1A1 (0.63) | LMNAALDH1A1GAAMAPTMEN1 | |
| SCHEMBL7753943 | 0.84 | MEN1 (0.58) | LMNAALDH1A1RAB9AGAAMAPT | |
| SCHEMBL7754088 | 0.82 | KMT2A (0.58) | LMNAALDH1A1MAPTKMT2AMAPK1 | |
| SCHEMBL7752904 | 0.81 | AKR1C4 (0.67) | RAB9AMAPTMEN1KMT2ANPC1 | |
| SCHEMBL6545821 | 0.81 | L3MBTL1 (0.68) | LMNAALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL6546924 | 0.81 | KMT2A (0.57) | LMNAALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL7753940 | 0.81 | KMT2A (0.59) | LMNAALDH1A1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1068176-A1 | CYSTEINE AMIDES AS FARNESYL TRANSFERASE INHIBITORS | Jomaa, Hassan (DE) | 2001-01-17 | — | — | EP | disclosed |
| WO-2000027803-A1 | CYSTEINE AMIDES AS FARNESYL TRANSFERASE INHIBITORS | JOMAA, HASSAN (DE) | 2000-05-18 | — | — | WO | disclosed |