Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.48 |
| ▸ | GSK3B | P49841 | 4/20 | 0.46 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.42 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.42 |
| ▸ | TDP2 | O95551 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | STK10 | O94804 | 1/20 | 0.40 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.40 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.39 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | CTRC | Q99895 | 1/20 | 0.39 |
| ▸ | NAT1 | P18440 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL91967 | 1.00 | PTGS2 (0.48) | PTGS2GSK3BMAOAMAOBSIRT2 | |
| SCHEMBL278635 | 0.95 | GSK3B (0.48) | PTGS2GSK3BMAOAMAOBALDH1A1 | |
| SCHEMBL12577696 | 0.90 | ALDH1A1 (0.56) | PTGS2GSK3BMAOAMAOBSIRT2 | |
| SCHEMBL92072 | 0.90 | CYP1A2 (0.56) | PTGS2GSK3BTDP2CTRC | |
| SCHEMBL12640639 | 0.90 | PTGS2 (0.42) | PTGS2GSK3BMAOAMAOBSIRT2 | |
| SCHEMBL9833136 | 0.88 | PTGS2 (0.47) | PTGS2GSK3BMAOAMAOBALDH1A1 | |
| SCHEMBL8502944 | 0.88 | PTGS1 (0.46) | PTGS2GSK3BSTK10SLK | |
| SCHEMBL12577691 | 0.88 | ALDH1A1 (0.52) | PTGS2GSK3BTDP2ALDH1A1 | |
| SCHEMBL1557806 | 0.88 | GSK3B (0.54) | PTGS2GSK3B | |
| SCHEMBL13578991 | 0.86 | TAAR1 (0.60) | PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0765919-B1 | Monophasic solid solutions with asymmetrical pyrrolo-(4-3-c)-pyrroles as host | CIBA SC HOLDING AG (CH) | 2001-02-21 | — | — | EP | disclosed |
| US-5821373-A | WITH DIFFERENT 1,4-DIKETOPYRROLOPYRROLE OR QUINACRIDONE; PIGMENTING HIGH MOLECULAR WEIGHT MATERIALS | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 1998-10-13 | — | — | US | disclosed |
| US-5756746-A | KETOPYRROLES AND QUINACRIDONES FOR LIGHT STABLE AND WEATHER RESISTANT COLOR COMPOSITIONS | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 1998-05-26 | — | — | US | disclosed |
| EP-0765919-A2 | Monophasic solid solutions with asymmetrical pyrrolo-(4-3-c)-pyrroles as host | Ciba SC Holding AG (CH) | 1997-04-02 | — | — | EP | disclosed |