Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLG | P00747 | 1/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | PLAT | P00750 | 1/20 | 0.39 |
| ▸ | KLK1 | P06870 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | RXRB | P28702 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14999424 | 0.74 | HTR2C (0.69) | PLGPLAUPLATKLK1HTR2C | |
| SCHEMBL10401412 | 0.71 | HTR2C (0.57) | HTR2CHTR6 | |
| SCHEMBL4169709 | 0.71 | SLC18A3 (0.42) | SMN1; SMN2KMT2AGAA | |
| Hydrochloric Acid SCHEMBL4473284 | 0.70 | SLC18A3 (0.41) | SMN1; SMN2KMT2AGAA | |
| SCHEMBL3854914 | 0.69 | PLG (0.41) | PLGPLAUPLATKLK1HTR2C | |
| SCHEMBL1364503 | 0.68 | HTR2C (0.45) | PLGPLAUPLATKLK1HTR2C | |
| SCHEMBL6227444 | 0.68 | LMNA (0.50) | MEN1KMT2AGAAKDM4E | |
| SCHEMBL2968363 | 0.67 | RXRA (0.53) | TP53SMN1; SMN2MEN1KMT2AGAA | |
| SCHEMBL14382847 | 0.67 | PLG (0.47) | PLGPLAUPLATKLK1HTR2C | |
| SCHEMBL13647244 | 0.64 | SLC6A2 (0.45) | PLGPLAUPLATSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077940-A1 | 4-PHENYLPIPERIDINES FOR THE TREATMENT OF PRURITIC DERMATOSES | PFIZER INC. (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999059971-A1 | NOVEL 4-PHENYLPIPERIDINES FOR THE TREATMENT OF PRURITIC DERMATOSES | PFIZER INC. (US) | 1999-11-25 | — | — | WO | disclosed |