Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 16/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 16/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 16/20 | 0.39 |
| ▸ | MAOB | P27338 | 4/20 | 0.39 |
| ▸ | MAOA | P21397 | 3/20 | 0.39 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7755736 | 0.83 | ADRA2A (0.40) | ADRA2AADRA2BADRA2CMAOBMAOA | |
| SCHEMBL6668824 | 0.77 | HTR7 (0.62) | MAOBHTR7ALDH1A1MAPT | |
| SCHEMBL7807464 | 0.77 | ENPP1 (0.44) | ADRA2AADRA2BADRA2CMAOBMAOA | |
| SCHEMBL6670384 | 0.69 | HTR7 (0.50) | MAOBHTR7ALDH1A1MAPT | |
| SCHEMBL6668813 | 0.68 | HTR7 (0.62) | HTR7ALDH1A1ATR | |
| SCHEMBL9544981 | 0.65 | GABRA1 (0.52) | ALDH1A1MAPTESR2 | |
| SCHEMBL31678675 | 0.65 | GABRA1 (0.52) | ALDH1A1MAPTESR2 | |
| SCHEMBL7957183 | 0.64 | SMN1; SMN2 (0.50) | ALDH1A1MAPT | |
| SCHEMBL3399496 | 0.63 | CHRNA7 (0.47) | MAOBALDH1A1MAPTATR | |
| SCHEMBL7807451 | 0.62 | ADRA2A (0.53) | ADRA2AADRA2BADRA2CALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077950-A1 | NOVEL DIPHENYL-SUBSTITUTED 6-RING-HETEROCYCLES, METHODS FOR PRODUCING THEM AND THEIR USE AS MEDICAMENTS | Boehringer Ingelheim Pharma KG (DE) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999054311-A1 | NOVEL DIPHENYL-SUBSTITUTED 6-RING-HETEROCYCLES, METHODS FOR PRODUCING THEM AND THEIR USE AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1999-10-28 | — | — | WO | disclosed |