Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | PKM | P14618 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | GHSR | Q92847 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | PKLR | P30613 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6659963 | 0.81 | OPRM1 (0.43) | BRD4ALDH1A1 | |
| SCHEMBL6659961 | 0.81 | OPRM1 (0.43) | BRD4ALDH1A1 | |
| SCHEMBL7756380 | 0.80 | KMT2A (0.47) | BRD4KMT2AALDH1A1HTTGAA | |
| SCHEMBL7756374 | 0.80 | KMT2A (0.47) | BRD4KMT2AALDH1A1HTTGAA | |
| SCHEMBL6653711 | 0.77 | OPRM1 (0.47) | BRD4MEN1KMT2APKMALDH1A1 | |
| SCHEMBL6653714 | 0.77 | OPRM1 (0.47) | BRD4MEN1KMT2APKMALDH1A1 | |
| SCHEMBL6656153 | 0.77 | TSHR (0.43) | MEN1KMT2AALDH1A1GAAHTR6 | |
| SCHEMBL6661166 | 0.77 | TSHR (0.43) | MEN1KMT2AALDH1A1GAAHTR6 | |
| SCHEMBL7754596 | 0.77 | PKM (0.45) | MEN1KMT2APKMALDH1A1HTT | |
| SCHEMBL6658605 | 0.77 | HTR7 (0.47) | BRD4MEN1KMT2AGHSRPKLR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077940-A1 | 4-PHENYLPIPERIDINES FOR THE TREATMENT OF PRURITIC DERMATOSES | PFIZER INC. (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999059971-A1 | NOVEL 4-PHENYLPIPERIDINES FOR THE TREATMENT OF PRURITIC DERMATOSES | PFIZER INC. (US) | 1999-11-25 | — | — | WO | disclosed |