Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 15/20 | 0.64 |
| ▸ | RARG | P13631 | 13/20 | 0.64 |
| ▸ | RXRA | P19793 | 11/20 | 0.64 |
| ▸ | RXRB | P28702 | 7/20 | 0.64 |
| ▸ | RXRG | P48443 | 5/20 | 0.64 |
| ▸ | RARA | P10276 | 11/20 | 0.59 |
| ▸ | CYP26A1 | O43174 | 5/20 | 0.59 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | GMNN | O75496 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16523407 | 0.86 | RARB (0.74) | RARBRARGRXRARXRBRXRG | |
| SCHEMBL8733241 | 0.86 | RARB (0.83) | RARBRARGRXRARXRBRXRG | |
| SCHEMBL7759698 | 0.85 | RXRA (0.64) | RARBRARGRXRARXRBRXRG | |
| SCHEMBL2194599 | 0.84 | RARB (0.82) | RARBRARGRXRARXRBRXRG | |
| SCHEMBL7761329 | 0.84 | RARB (0.80) | RARBRARGRXRARXRBRXRG | |
| SCHEMBL7899482 | 0.80 | RXRA (0.61) | RARBRARGRXRARXRBRXRG | |
| SCHEMBL24259973 | 0.78 | RXRA (0.77) | RARBRARGRXRARXRBRXRG | |
| SCHEMBL10355871 | 0.78 | RXRA (1.00) | RARBRARGRXRARXRBRXRG | |
| SCHEMBL7756637 | 0.78 | RXRA (0.58) | RARBRARGRXRARXRBRXRG | |
| SCHEMBL3843601 | 0.77 | ATM (0.60) | ALDH1A1MEN1KMT2ANPC1MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6258775-B1 | 3-(3-(5,5,8,8-TETRAMATHYL-5,6,7,8-TETRAHYDRO-2-NAPHTYLCARBONYL )PHENYL)ACRYLIC ACID FOR TREATING DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, AND OPHTHALMOLOGICAL DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2001-07-10 | — | — | US | disclosed |
| EP-0915823-B1 | BI-AROMATIC COMPOUNDS, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME AND USES | CT INTERNAT DE (FR) | 2001-04-18 | — | — | EP | disclosed |
| EP-0915823-A1 | BI-AROMATIC COMPOUNDS, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME AND USES | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA - CIRD GALDERMA (FR) | 1999-05-19 | — | — | EP | disclosed |
| WO-1998022423-A1 | BI-AROMATIC COMPOUNDS, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME AND USES | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (C.I.R.D. GALDERMA) (FR) | 1998-05-28 | — | — | WO | disclosed |