SCHEMBL7756591

SCHEMBL7756591

CCNC(=O)/C=C/c1ccccc1C1(c2cc3c(cc2C)C(C)(C)CCC3(C)C)CC1

nearest known ligand 0.44

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
RXRA P19793 14/20 0.44
ALDH1A1 P00352 1/20 0.44
RXRG P48443 10/20 0.40
RXRB P28702 10/20 0.40
RARG P13631 5/20 0.40
RARB P10826 4/20 0.40
RARA P10276 3/20 0.40
PPARG P37231 1/20 0.40
SLC6A19 Q695T7 1/20 0.38
GNRHR P30968 1/20 0.36
NPC1 O15118 1/20 0.34
LMNA P02545 1/20 0.34
HPGD P15428 1/20 0.34
RAB9A P51151 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7761278 1.00 RXRA (0.44) RXRAALDH1A1RXRGRXRBRARG
SCHEMBL7760198 0.85 ALDH1A1 (0.46) RXRAALDH1A1RXRGRXRBRARG
SCHEMBL7760202 0.85 ALDH1A1 (0.46) RXRAALDH1A1RXRGRXRBRARG
SCHEMBL7761270 0.84 RXRA (0.52) RXRARXRGRXRBRARGRARB
SCHEMBL7761215 0.84 RXRA (0.52) RXRARXRGRXRBRARGRARB
SCHEMBL7761548 0.83 RXRA (0.48) RXRARXRGRXRBRARGRARB
SCHEMBL6870432 0.83 RXRA (0.46) RXRAALDH1A1RXRGRXRBRARG
SCHEMBL7761497 0.82 MAOA (0.48) RXRARARBNPC1LMNARAB9A
SCHEMBL7761494 0.82 MAOA (0.48) RXRARARBNPC1LMNARAB9A
SCHEMBL7760266 0.81 SLC6A19 (0.49) RXRAALDH1A1RXRGRXRBRARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6258775-B1 3-(3-(5,5,8,8-TETRAMATHYL-5,6,7,8-TETRAHYDRO-2-NAPHTYLCARBONYL )PHENYL)ACRYLIC ACID FOR TREATING DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, AND OPHTHALMOLOGICAL DISORDERS CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) 2001-07-10 US claimed
EP-0915823-B1 BI-AROMATIC COMPOUNDS, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME AND USES CT INTERNAT DE (FR) 2001-04-18 EP claimed
US-6258775-B1 3-(3-(5,5,8,8-TETRAMATHYL-5,6,7,8-TETRAHYDRO-2-NAPHTYLCARBONYL )PHENYL)ACRYLIC ACID FOR TREATING DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, AND OPHTHALMOLOGICAL DISORDERS CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) 2001-07-10 US disclosed
EP-0915823-B1 BI-AROMATIC COMPOUNDS, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME AND USES CT INTERNAT DE (FR) 2001-04-18 EP disclosed