Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 2/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.52 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | CES1 | P23141 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17446096 | 0.88 | ALDH1A1 (0.56) | TSHRALDH1A1MAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL6200667 | 0.81 | TSHR (0.63) | TSHRALDH1A1MAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL777871 | 0.81 | GABBR2 (0.53) | MAPTLMNAMAPK1CES1CYP2C19 | |
| SCHEMBL9066674 | 0.79 | ATM (0.74) | TSHRALDH1A1MAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL2141566 | 0.78 | PDPK1 (0.78) | TSHRALDH1A1MAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL22319291 | 0.78 | CES2 (0.48) | ALDH1A1MAPTKDM4ELMNAKMT2A | |
| SCHEMBL7050949 | 0.78 | TSHR (0.59) | TSHRALDH1A1MAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL2655629 | 0.78 | CES2 (0.48) | ALDH1A1MAPTKDM4ELMNAKMT2A | |
| SCHEMBL7470869 | 0.78 | CYP2C19 (0.51) | ALDH1A1SMN1; SMN2L3MBTL1LMNANPSR1 | |
| SCHEMBL3077522 | 0.78 | TSHR (0.59) | TSHRALDH1A1MAPTSMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1309637-A | Compositions comprising 2-phenyl-indole compounds and estrogen formutations | AMERICAN HOME PROD (US) | 2001-08-22 | — | — | CN | disclosed |
| EP-1080073-A1 | COMPOSITIONS COMPRISING 2-PHENYL-INDOLE COMPOUNDS AND ESTROGEN FORMULATIONS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-03-07 | — | — | EP | disclosed |
| WO-1999059969-A1 | COMPOSITIONS COMPRISING 2-PHENYL-INDOLE COMPOUNDS AND ESTROGEN FORMULATIONS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-11-25 | — | — | WO | disclosed |
| EP-0197752-B1 | PHARMACEUTICAL COMPOSITIONS | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1990-09-12 | — | — | EP | disclosed |