SCHEMBL7758085

SCHEMBL7758085

C=CCN=C(NC#N)NCCCCC

nearest known ligand 0.46

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.46
ZDHHC20 Q5W0Z9 2/20 0.39
ZDHHC2 Q9UIJ5 2/20 0.39
HRH4 Q9H3N8 5/20 0.37
SMN1; SMN2 Q16637 1/20 0.36
CYP1A2 P05177 1/20 0.35
GAA P10253 1/20 0.35
CYP2D6 P10635 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
HRH3 Q9Y5N1 1/20 0.34
QPCT Q16769 2/20 0.34
EPHX1 P07099 4/20 0.33
KDM4E B2RXH2 1/20 0.33
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
HSD17B10 Q99714 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7758081 1.00 ALDH1A1 (0.46) ALDH1A1ZDHHC20ZDHHC2HRH4SMN1; SMN2
SCHEMBL7753802 0.81 HRH4 (0.45) HRH4HRH3
SCHEMBL7753798 0.81 HRH4 (0.45) HRH4HRH3
SCHEMBL10578435 0.77 ALDH1A1 (0.54) ALDH1A1SMN1; SMN2CYP1A2GAACYP2D6
SCHEMBL7758091 0.76 HRH4 (0.41) ALDH1A1HRH4CYP2D6CYP2C9CYP2C19
SCHEMBL11484378 0.76 HRH4 (0.51) ZDHHC20ZDHHC2HRH4SMN1; SMN2CYP1A2
SCHEMBL11527425 0.72 GRIN2D (0.39) HRH4QPCT
SCHEMBL11527422 0.72 GRIN2D (0.39) HRH4QPCT
SCHEMBL14208779 0.70 GRIN2D (0.40) ZDHHC20ZDHHC2SMN1; SMN2CYP1A2MEN1
SCHEMBL13684632 0.70 GRIN2D (0.40) ZDHHC20ZDHHC2SMN1; SMN2CYP1A2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1077933-A1 SUBSTITUTED GUANIDINES AND DIAMINONITROETHENES, THEIR PREPARATION AND USE NOVO NORDISK A/S (DK) 2001-02-28 EP disclosed
US-6147098-A USEFUL IN THE TREATMENT OF DISEASES OF THE CENTRAL NERVOUS SYSTEM, CARDIOVASCULAR SYSTEM, PULMONARY SYSTEM, GASTROINTESTINAL SYSTEM AND ENDOCRINOLOGIC SYSTEM NOVO NORDISK A/S (DK) 2000-11-14 US disclosed
WO-1999058497-A1 SUBSTITUTED GUANIDINES AND DIAMINONITROETHENES, THEIR PREPARATION AND USE NOVO NORDISK A/S (DK) 1999-11-18 WO disclosed