Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 9/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 9/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 9/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.57 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.57 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.57 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.57 |
| ▸ | NCOR2 | Q9Y618 | 4/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.53 |
| ▸ | MMP3 | P08254 | 1/20 | 0.51 |
| ▸ | MMP9 | P14780 | 1/20 | 0.51 |
| ▸ | MMP8 | P22894 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16620624 | 0.90 | TAAR1 (0.57) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL7016639 | 0.82 | HDAC2 (0.59) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL29025356 | 0.81 | EPHX2 (0.57) | HDAC3HDAC1HDAC2HDAC6NCOR2 | |
| SCHEMBL7758247 | 0.81 | SMN1; SMN2 (0.50) | L3MBTL1MMP3MMP9MMP8LMNA | |
| SCHEMBL15894527 | 0.81 | LMNA (0.53) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL17117375 | 0.80 | TAAR1 (0.72) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL25375626 | 0.80 | LMNA (0.55) | L3MBTL1LMNAKDM4EEPHX2TSHR | |
| SCHEMBL7694478 | 0.80 | L3MBTL1 (0.58) | L3MBTL1MMP3MMP9MMP8LMNA | |
| SCHEMBL7682044 | 0.80 | LMNA (0.69) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL3356126 | 0.79 | SMN1; SMN2 (0.58) | HDAC3HDAC1HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0821666-B1 | DERIVATIVES OF SUCCINAMIDE AND THEIR USE AS METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARM (GB) | 2000-12-27 | — | — | EP | claimed |