Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 2/20 | 0.62 |
| ▸ | ECE1 | P42892 | 1/20 | 0.51 |
| ▸ | MMP2 | P08253 | 15/20 | 0.49 |
| ▸ | MMP3 | P08254 | 6/20 | 0.49 |
| ▸ | PTAFR | P25105 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | MMP7 | P09237 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.45 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.45 |
| ▸ | PRKACA | P17612 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | GSK3A | P49840 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.45 |
| ▸ | PRKX | P51817 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.45 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7758513 | 1.00 | MMP12 (0.62) | MMP12ECE1MMP2MMP3PTAFR | |
| SCHEMBL6270502 | 0.92 | MMP12 (0.64) | MMP12ECE1MMP2MMP3MMP1 | |
| SCHEMBL6270497 | 0.92 | MMP12 (0.64) | MMP12ECE1MMP2MMP3MMP1 | |
| SCHEMBL7765152 | 0.90 | MMP2 (0.55) | MMP12MMP2MMP3MMP1MMP7 | |
| SCHEMBL7763746 | 0.85 | MMP2 (0.49) | MMP12MMP2MMP3MMP1MMP7 | |
| SCHEMBL7763742 | 0.85 | MMP2 (0.49) | MMP12MMP2MMP3MMP1MMP7 | |
| SCHEMBL7762298 | 0.80 | MMP2 (0.45) | MMP12MMP2MMP3MMP1 | |
| SCHEMBL7762305 | 0.80 | MMP2 (0.45) | MMP12MMP2MMP3MMP1 | |
| SCHEMBL7762293 | 0.80 | MMP2 (0.45) | MMP12MMP2MMP3MMP1 | |
| SCHEMBL7762278 | 0.77 | MMP12 (0.50) | MMP12MMP2MMP3PTAFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098662-A2 | COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS | WARNER-LAMBERT COMPANY (US) | 2001-05-16 | — | — | EP | disclosed |
| WO-2000004892-A2 | COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS | WARNER-LAMBERT COMPANY (US) | 2000-02-03 | — | — | WO | disclosed |